| Literature DB >> 2033578 |
R L Dow1, B M Bechle, T T Chou, D A Clark, B Hulin, R W Stevenson.
Abstract
A series of benzyloxazolidine-2,4-diones, containing oxazole-based side chains, were found to lower blood glucose levels in the genetically obese ob/ob mouse. Incorporation of a benzofuran structural element in these compounds provides greatly enhanced in vivo potency. The syntheses and structure-activity relationships for this series are detailed.Entities:
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Year: 1991 PMID： 2033578 DOI： 10.1021/jm00109a003
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446