BACKGROUND: Psychological functioning is an important determinant of health outcomes in chronic lung disease. To better define the role of anxiety in chronic obstructive pulmonary disease (COPD), a study was conducted of the inter-relations between anxiety and COPD in a large cohort of subjects with COPD and a matched control group. METHODS: Data were used from the FLOW (Function, Living, Outcomes, and Work) cohort of patients with COPD (n=1202) and matched controls without COPD (n=302). Anxiety was measured using the Anxiety subscale of the Hospital Anxiety and Depression Scale. RESULTS: COPD was associated with a greater risk of anxiety in multivariable analysis (OR 1.85; 95% CI 1.072 to 3.18). Among patients with COPD, anxiety was related to poorer health outcomes including worse submaximal exercise performance (less distance walked during the 6-min walk test: -66.3 feet for anxious vs non-anxious groups; 95% CI -127.3 to -5.36) and a greater risk of self-reported functional limitations (OR 2.41; 95% CI 1.71 to 3.41). Subjects with COPD with anxiety had a higher longitudinal risk of COPD exacerbation in Cox proportional hazards analysis after controlling for covariates (HR 1.39; 95% CI 1.007 to 1.90). CONCLUSION: COPD is associated with a higher risk of anxiety. Once anxiety develops among patients with COPD, it is related to poorer health outcomes. Further research is needed to determine whether systematic screening and treatment of anxiety in COPD will improve health outcomes and prevent functional decline and disability.
BACKGROUND: Psychological functioning is an important determinant of health outcomes in chronic lung disease. To better define the role of anxiety in chronic obstructive pulmonary disease (COPD), a study was conducted of the inter-relations between anxiety and COPD in a large cohort of subjects with COPD and a matched control group. METHODS: Data were used from the FLOW (Function, Living, Outcomes, and Work) cohort of patients with COPD (n=1202) and matched controls without COPD (n=302). Anxiety was measured using the Anxiety subscale of the Hospital Anxiety and Depression Scale. RESULTS:COPD was associated with a greater risk of anxiety in multivariable analysis (OR 1.85; 95% CI 1.072 to 3.18). Among patients with COPD, anxiety was related to poorer health outcomes including worse submaximal exercise performance (less distance walked during the 6-min walk test: -66.3 feet for anxious vs non-anxious groups; 95% CI -127.3 to -5.36) and a greater risk of self-reported functional limitations (OR 2.41; 95% CI 1.71 to 3.41). Subjects with COPD with anxietyhad a higher longitudinal risk of COPD exacerbation in Cox proportional hazards analysis after controlling for covariates (HR 1.39; 95% CI 1.007 to 1.90). CONCLUSION:COPD is associated with a higher risk of anxiety. Once anxiety develops among patients with COPD, it is related to poorer health outcomes. Further research is needed to determine whether systematic screening and treatment of anxiety in COPD will improve health outcomes and prevent functional decline and disability.
Authors: Gunnar Gudmundsson; Thorarinn Gislason; Christer Janson; Eva Lindberg; Charlotte Suppli Ulrik; Eva Brøndum; Markku M Nieminen; Tiina Aine; Runa Hallin; Per Bakke Journal: Respir Med Date: 2006-01 Impact factor: 3.415
Authors: Frank Sciurba; Gerard J Criner; Shing M Lee; Zab Mohsenifar; David Shade; William Slivka; Robert A Wise Journal: Am J Respir Crit Care Med Date: 2003-02-20 Impact factor: 21.405
Authors: Stephen Sidney; Michael Sorel; Charles P Quesenberry; Cynthia DeLuise; Stephan Lanes; Mark D Eisner Journal: Chest Date: 2005-10 Impact factor: 9.410
Authors: G H Guyatt; M J Sullivan; P J Thompson; E L Fallen; S O Pugsley; D W Taylor; L B Berman Journal: Can Med Assoc J Date: 1985-04-15 Impact factor: 8.262
Authors: Theodore A Omachi; Patricia P Katz; Edward H Yelin; Steven E Gregorich; Carlos Iribarren; Paul D Blanc; Mark D Eisner Journal: Am J Med Date: 2009-08 Impact factor: 4.965
Authors: Janet Maurer; Venkata Rebbapragada; Soo Borson; Roger Goldstein; Mark E Kunik; Abebaw M Yohannes; Nicola A Hanania Journal: Chest Date: 2008-10 Impact factor: 9.410
Authors: Hasan Kahraman; Fatma Ozlem Orhan; Mustafa Haki Sucakli; Ali Ozer; Nurhan Koksal; Bilal Sen Journal: J Thorac Dis Date: 2013-08 Impact factor: 2.895
Authors: Samantha G Farris; Ana M Abrantes; Dale S Bond; Loren M Stabile; Wen-Chih Wu Journal: J Cardiopulm Rehabil Prev Date: 2019-03 Impact factor: 2.081