Literature DB >> 20333346

[Withdrawal in a patient with an implantable drug delivery system in spite of continuation of opiate therapy].

S Lochner1, U Heinrich-Gräfe, W Kirch.   

Abstract

A male patient with severe chronic pain has been treated with a combined drug therapy scheme of morphine and clonidine. After cessation of clonidine the patient reported opiate-withdrawal symptoms with agitation, polyuria, diarrhea, and hyperalgesia. It is known that the combination of these two substances causes synergistic analgetic effects. The abrupt cessation of clonidine after a combined administration with morphine seems to lead to a relative decrease in opiate effects and furthermore excite opiate-withdrawal symptoms.

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Year:  2010        PMID： 20333346     DOI： 10.1007/s00108-009-2545-1

Source DB:  PubMed          Journal:  Internist (Berl)        ISSN： 0020-9554            Impact factor:   0.743


  9 in total

Review 1.  Clinical guidelines for intraspinal infusion: report of an expert panel. PolyAnalgesic Consensus Conference 2000.

Authors:  G Bennett; K Burchiel; E Buchser; A Classen; T Deer; S Du Pen; F M Ferrante; S J Hassenbusch; L Lou; J Maeyaert; R Penn; R K Portenoy; R Rauck; M Serafini; K D Willis; T Yaksh
Journal:  J Pain Symptom Manage       Date:  2000-08       Impact factor: 3.612

2.  Continuous intrathecal clonidine administration for the treatment of neuropathic pain.

Authors:  E I Uhle; R Becker; S Gatscher; H Bertalanffy
Journal:  Stereotact Funct Neurosurg       Date:  2000       Impact factor: 1.875

3.  [Current aspects of the use of clonidine].

Authors:  E Verspohl
Journal:  Pharm Unserer Zeit       Date:  1983-07

Review 4.  [Importance of intrathecal pain therapy].

Authors:  R Likar; W Ilias; H Kloimstein; A Kofler; H G Kress; J Neuhold; M M Pinter; M C Spendel
Journal:  Schmerz       Date:  2007-02       Impact factor: 1.107

5.  Mutual potentiation of antinociceptive effects of morphine and clonidine on motor and sensory responses in rat spinal cord.

Authors:  G L Wilcox; K H Carlsson; A Jochim; I Jurna
Journal:  Brain Res       Date:  1987-03-03       Impact factor: 3.252

6.  A controlled comparison of buprenorphine and clonidine for acute detoxification from opioids.

Authors:  L J Cheskin; P J Fudala; R E Johnson
Journal:  Drug Alcohol Depend       Date:  1994-10       Impact factor: 4.492

7.  Clonidine blocks acute opiate-withdrawal symptoms.

Authors:  M S Gold; D E Redmond; H D Kleber
Journal:  Lancet       Date:  1978-09-16       Impact factor: 79.321

8.  Opioid detoxification with buprenorphine, clonidine, or methadone in hospitalized heroin-dependent patients with HIV infection.

Authors:  Annie Umbricht; Donald R Hoover; Marvin J Tucker; Jo M Leslie; Richard E Chaisson; Kenzie L Preston
Journal:  Drug Alcohol Depend       Date:  2003-04-01       Impact factor: 4.492

9.  [Spinal administration of alpha 2-adrenoceptor agonists and opioids or local anaesthetic agents].

Authors:  J Motsch
Journal:  Schmerz       Date:  1996-02-15       Impact factor: 1.107
  9 in total
  1 in total

1.  Programmable transdermal clonidine delivery through voltage-gated carbon nanotube membranes.

Authors:  Caroline Strasinger; Kalpana S Paudel; Ji Wu; Dana Hammell; Raghotham R Pinninti; Bruce J Hinds; Audra Stinchcomb
Journal:  J Pharm Sci       Date:  2014-05-01       Impact factor: 3.534
  1 in total

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