| Literature DB >> 20332578 |
Yang Zhang1, Jinyun Peng, Yunlian Tang, Jie He, Juan Peng, Qiang Zhao, Rongfang He, Xiaoli Xie, Xueqin Peng, Runliang Gan.
Abstract
To analyze the association of several types of malignant lymphomas in different anatomical sites with the Epstein-Barr virus (EBV) infection status, 127 cases of formalin-fixed paraffin-embedded samples of malignant lymphomas were investigated with in situ hybridization detecting EBV-encoded small RNA (EBER) in tumor cells. Forty-six out of 108 non-Hodgkin lymphoma (NHL) cases were positive for EBER (42.6%). The EBER-positivity rate of NHL in the nasal cavity and nasopharynx (35/60 cases, 58.3%) was higher than that of NHL in stomach (9/30 cases, 30%) and in the superficial lymph nodes (2/18 cases, 11.1%) (P<0.05). The EBER-positivity rate of Hodgkin lymphoma in the superficial lymph nodes was 26.3% (5/19 cases). These findings suggest that the EBV-positivity rate in lymphomas is related to their histological types and locations.Entities:
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Year: 2010 PMID: 20332578
Source DB: PubMed Journal: Jpn J Infect Dis ISSN: 1344-6304 Impact factor: 1.362