BACKGROUND: Polymorphisms of interleukin-1 beta gene (IL1B-511C>T) are considered as risk factor for gastric carcinogenesis, but conflicting data have been reported recently. PATIENTS AND METHODS: The distribution of the four major IL1B variants (IL1B-3737C>T, -1464G>C, - 511C>T, -31T>C) were analyzed in 116 and 142 patients with gastric cancer and 'high risk gastritis', respectively, as well as 94 healthy controls. RESULTS: While identified frequencies of genotypes, haplotypes and haplotype pairs corresponded to those of other studies in Caucasians, none were significantly associated with the presence of gastric cancer or premalignant alterations. CONCLUSION: None of the four major polymorphisms is individually or in its haplotype configuration linked to the development of GC in this Caucasian population in Germany.
BACKGROUND: Polymorphisms of interleukin-1 beta gene (IL1B-511C>T) are considered as risk factor for gastric carcinogenesis, but conflicting data have been reported recently. PATIENTS AND METHODS: The distribution of the four major IL1B variants (IL1B-3737C>T, -1464G>C, - 511C>T, -31T>C) were analyzed in 116 and 142 patients with gastric cancer and 'high risk gastritis', respectively, as well as 94 healthy controls. RESULTS: While identified frequencies of genotypes, haplotypes and haplotype pairs corresponded to those of other studies in Caucasians, none were significantly associated with the presence of gastric cancer or premalignant alterations. CONCLUSION: None of the four major polymorphisms is individually or in its haplotype configuration linked to the development of GC in this Caucasian population in Germany.
Authors: Małgorzata Skierucha; Anya Na Milne; G Johan A Offerhaus; Wojciech P Polkowski; Ryszard Maciejewski; Robert Sitarz Journal: World J Gastroenterol Date: 2016-02-28 Impact factor: 5.742
Authors: Juozas Kupcinskas; Thomas Wex; Jan Bornschein; Michael Selgrad; Marcis Leja; Elona Juozaityte; Gediminas Kiudelis; Laimas Jonaitis; Peter Malfertheiner Journal: BMC Med Genet Date: 2011-08-24 Impact factor: 2.103
Authors: María Carolina Sanabria-Salas; Gustavo Hernández-Suárez; Adriana Umaña-Pérez; Konrad Rawlik; Albert Tenesa; Martha Lucía Serrano-López; Myriam Sánchez de Gómez; Martha Patricia Rojas; Luis Eduardo Bravo; Rosario Albis; José Luis Plata; Heather Green; Theodor Borgovan; Li Li; Sumana Majumdar; Jone Garai; Edward Lee; Hassan Ashktorab; Hassan Brim; Li Li; David Margolin; Laura Fejerman; Jovanny Zabaleta Journal: Sci Rep Date: 2017-02-03 Impact factor: 4.379