Literature DB >> 20332452

Anthraquinones danthron and quinizarin exert antiproliferative and antimetastatic activity on murine B16-F10 melanoma cells.

Stefania Rossi1, Claudio Tabolacci, Alessandro Lentini, Bruno Provenzano, Fabrizio Carlomosti, Simona Frezzotti, Simone Beninati.   

Abstract

The anticancer potential of anthraquinones danthron and quinizarin on highly metastatic B16-F10 melanoma murine cells was investigated. Several parameters related to cell proliferation and differentiation, i.e. cell number, intracellular content of polyamines, transglutaminase (EC 2.3.2.13) activity and melanin synthesis were evaluated. Tumor cell growth was strongly reduced after treatment with danthron and quinizarin, as well as polyamine intracellular levels. Moreover, the induction of differentiation in treated cells was demonstrated by the increase of transglutaminase activity. In vitro analysis of adhesion, wound healing migration and invasion showed a remarkable antimetastatic activity of the anthraquinones. The overall results suggest that danthron and quinizarin possess significant antineoplastic properties, probably exerted through the induction of intracellular transglutaminase activity.

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Year:  2010        PMID： 20332452

Source DB:  PubMed          Journal:  Anticancer Res        ISSN： 0250-7005            Impact factor:   2.480


  6 in total

1.  Spermidine delays eye lens opacification in vitro by suppressing transglutaminase-catalyzed crystallin cross-linking.

Authors:  Alessandro Lentini; Claudio Tabolacci; Palma Mattioli; Bruno Provenzano; Simone Beninati
Journal:  Protein J       Date:  2011-02       Impact factor: 2.371

Review 2.  Transglutaminase is a tumor cell and cancer stem cell survival factor.

Authors:  Richard L Eckert; Matthew L Fisher; Dan Grun; Gautam Adhikary; Wen Xu; Candace Kerr
Journal:  Mol Carcinog       Date:  2015-08-10       Impact factor: 4.784

3.  Danthron activates AMP-activated protein kinase and regulates lipid and glucose metabolism in vitro.

Authors:  Rong Zhou; Ling Wang; Xing Xu; Jing Chen; Li-hong Hu; Li-li Chen; Xu Shen
Journal:  Acta Pharmacol Sin       Date:  2013-06-17       Impact factor: 6.150

4.  Antiproliferative, DNA binding, and cleavage properties of dinuclear Co(III) complexes containing the bioactive quinizarin ligand.

Authors:  Hana Crlikova; Hana Kostrhunova; Jitka Pracharova; Máté Kozsup; Sándor Nagy; Péter Buglyó; Viktor Brabec; Jana Kasparkova
Journal:  J Biol Inorg Chem       Date:  2020-02-28       Impact factor: 3.358

5.  1-Amino-4-hydroxy-9,10-anthraquinone - An analogue of anthracycline anticancer drugs, interacts with DNA and induces apoptosis in human MDA-MB-231 breast adinocarcinoma cells: Evaluation of structure-activity relationship using computational, spectroscopic and biochemical studies.

Authors:  Palash Mondal; Sanjay Roy; Gayathri Loganathan; Bitapi Mandal; Dhanasekaran Dharumadurai; Mohammad A Akbarsha; Partha Sarathi Sengupta; Shouvik Chattopadhyay; Partha Sarathi Guin
Journal:  Biochem Biophys Rep       Date:  2015-10-23

6.  A Co(III) Complex of 1-Amino-4-hydroxy-9,10-anthraquinone Exhibits Apoptotic Action against MCF-7 Human Breast Cancer Cells.

Authors:  Somenath Banerjee; Sanjay Roy; Dhanasekaran Dharumadurai; Balaji Perumalsamy; Ramasamy Thirumurugan; Saurabh Das; Asoke Prasun Chattopadhyay; Partha Sarathi Guin
Journal:  ACS Omega       Date:  2021-12-29
  6 in total

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