UNLABELLED: The aim of this study was to investigate the diagnostic value of tumor M2 pyrurate kinase (Tu-M2-PK) as a tumor marker in patients with pre-invasive (CIN), invasive (PCC) and recurrent (RCC) cervical cancer. MATERIALS AND METHODS: Plasma samples were investigated from 125 patients, comprising 50 cases of CIN (I-III), 51 of PCC (FIGO I-IV) and 24 of RCC, before treatment. Tu-M2-PK levels were determined by using a quantitative sandwich enzyme immunoassay. RESULTS: With the increase in disease severity from CIN to PCC to RCC, levels of Tu-M2-PK significantly increased (p<0.001). Levels of Tu-M2-PK significantly increased with respect to the FIGO stage (p<0.001) and had significantly higher values in node+ patients (p=0.028). There was no significant difference in Tu-M2-PK levels in CIN I-III patients (p=0.626). Patients with distant metastasis had significantly elevated levels of Tu-M2-PK (p<0.001). CONCLUSION: Tu-M2-PK can be used as a marker to differentiate between malignant and premalignant cervical lesions. In addition, the concentration of Tu-M2-PK correlates with the clinical stage of the disease.
UNLABELLED: The aim of this study was to investigate the diagnostic value of tumor M2 pyrurate kinase (Tu-M2-PK) as a tumor marker in patients with pre-invasive (CIN), invasive (PCC) and recurrent (RCC) cervical cancer. MATERIALS AND METHODS: Plasma samples were investigated from 125 patients, comprising 50 cases of CIN (I-III), 51 of PCC (FIGO I-IV) and 24 of RCC, before treatment. Tu-M2-PK levels were determined by using a quantitative sandwich enzyme immunoassay. RESULTS: With the increase in disease severity from CIN to PCC to RCC, levels of Tu-M2-PK significantly increased (p<0.001). Levels of Tu-M2-PK significantly increased with respect to the FIGO stage (p<0.001) and had significantly higher values in node+ patients (p=0.028). There was no significant difference in Tu-M2-PK levels in CIN I-IIIpatients (p=0.626). Patients with distant metastasis had significantly elevated levels of Tu-M2-PK (p<0.001). CONCLUSION: Tu-M2-PK can be used as a marker to differentiate between malignant and premalignant cervical lesions. In addition, the concentration of Tu-M2-PK correlates with the clinical stage of the disease.
Authors: Jennifer A Wittwer; Delira Robbins; Fei Wang; Sarah Codarin; Xinggui Shen; Christopher G Kevil; Ting-Ting Huang; Holly Van Remmen; Arlan Richardson; Yunfeng Zhao Journal: Cancer Prev Res (Phila) Date: 2011-06-14
Authors: Daniel Fatela-Cantillo; Antonio Fernandez-Suarez; Miguel Alonso Marin Moreno; Juan Jesus Puente Gutierrez; Jose Miguel Diaz Iglesias Journal: Tumour Biol Date: 2012-01-10
Authors: Bishoy A Gayed; Jessica Gillen; Alana Christie; Samuel Peña-Llopis; Xian-Jin Xie; Jingsheng Yan; Jose A Karam; Ganesh Raj; Arthur I Sagalowsky; Yair Lotan; Vitaly Margulis; James Brugarolas Journal: BMC Urol Date: 2015-04-03 Impact factor: 2.264