ETHNOPHARMACOLOGICAL RELEVANCE: Caryocar coriaceum Wittm. (Caryocaraceae), popularly known as pequi, is important source of food and used in the folk medicine as wound healing, anti-inflammatory and for the treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer. AIM OF THE STUDY: To evaluate the effects of fixed oil of Caryocar coriaceum (FOCC) on the topical inflammation and cutaneous wound healing. MATERIALS AND METHODS: FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% on model of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excision model in mice. Skin lesions were evaluated by planimetry and histological analysis. RESULTS: FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%) inhibited the ear edema in 38.01% and 39.20% at time 15 min and 1h, respectively, after induction of inflammation, when compared to the positive control. The topical administration of FOCC ointment 12% showed a significantly reduction of unhealed wound area, with increased percentage of wound contraction (96.54%) on day 7 when compared to the other groups. The results of histological evaluation supported the outcome of excision wound model. CONCLUSION: Caryocar coriaceum inhibits the topical inflammation and accelerate cutaneous wound repair. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
ETHNOPHARMACOLOGICAL RELEVANCE: Caryocar coriaceum Wittm. (Caryocaraceae), popularly known as pequi, is important source of food and used in the folk medicine as wound healing, anti-inflammatory and for the treatment of diseases of the respiratory tract, rheumatic and muscular pains and gastric ulcer. AIM OF THE STUDY: To evaluate the effects of fixed oil of Caryocar coriaceum (FOCC) on the topical inflammation and cutaneous wound healing. MATERIALS AND METHODS: FOCC was purchased commercially and used at 6%, 12%, 25%, 50% and 100% on model of ear edema induced by xylene and ointments formulations at 6% and 12% on wound excision model in mice. Skin lesions were evaluated by planimetry and histological analysis. RESULTS: FOCC was capable of reducing inflammation in a dose-dependent fashion. FOCC in nature (100%) inhibited the ear edema in 38.01% and 39.20% at time 15 min and 1h, respectively, after induction of inflammation, when compared to the positive control. The topical administration of FOCC ointment 12% showed a significantly reduction of unhealed wound area, with increased percentage of wound contraction (96.54%) on day 7 when compared to the other groups. The results of histological evaluation supported the outcome of excision wound model. CONCLUSION: Caryocar coriaceum inhibits the topical inflammation and accelerate cutaneous wound repair. Copyright 2010 Elsevier Ireland Ltd. All rights reserved.
Authors: Mirele da Silveira Vasconcelos; Neuza F Gomes-Rochette; Maria Liduína M de Oliveira; Diana Célia S Nunes-Pinheiro; Adriana R Tomé; Francisco Yuri Maia de Sousa; Francisco Geraldo M Pinheiro; Carlos Farley H Moura; Maria Raquel A Miranda; Erika Freitas Mota; Dirce Fernandes de Melo Journal: Exp Biol Med (Maywood) Date: 2015-03-27
Authors: Daniela Ribeiro Alves; Selene Maia de Morais; Fernanda Tomiotto-Pellissier; Milena Menegazzo Miranda-Sapla; Fábio Roger Vasconcelos; Isaac Neto Goes da Silva; Halisson Araujo de Sousa; João Paulo Assolini; Ivete Conchon-Costa; Wander Rogério Pavanelli; Francisco das Chagas Oliveira Freire Journal: Evid Based Complement Alternat Med Date: 2017-09-07 Impact factor: 2.629
Authors: José Weverton Almeida-Bezerra; José Jailson Lima Bezerra; Viviane Bezerra da Silva; Henrique Douglas Melo Coutinho; José Galberto Martins da Costa; Natália Cruz-Martins; Christophe Hano; Saulo Almeida de Menezes; Maria Flaviana Bezerra Morais-Braga; Antonio Fernando Morais de Oliveira Journal: Plants (Basel) Date: 2022-06-25