Literature DB >> 20331997

Detection and quantification of maitotoxin-like compounds using a neuroblastoma (Neuro-2a) cell based assay. Application to the screening of maitotoxin-like compounds in Gambierdiscus spp.

A Caillaud1, T Yasumoto, J Diogène.   

Abstract

SK&F 96365 was used in a Neuroblastoma (Neuro-2a) cell based assay to determine the production of maitotoxin-like (MTX-like) compounds in two strains of Gambierdiscus spp. A 2.5 hour assay was effective for the detection of the MTX-induced toxic effects with a concentration that inhibited 50% cell viability (IC(50)) equivalent to 3.38 nM MTX. Evidence was found for the production of MTX-like compounds in both Gambierdiscus strains studied at concentrations of 404 and 36.7 nmoles MTX equivalence per 10(6) cells. The assay is proposed as an efficient approach to the detection and quantification of MTX-like compounds in Gambierdiscus spp. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20331997     DOI： 10.1016/j.toxicon.2010.03.012

Source DB:  PubMed          Journal:  Toxicon        ISSN： 0041-0101            Impact factor:   3.033


  7 in total

Review 1.  Update on methodologies available for ciguatoxin determination: perspectives to confront the onset of ciguatera fish poisoning in Europe.

Authors:  Amandine Caillaud; Pablo de la Iglesia; H Taiana Darius; Serge Pauillac; Katerina Aligizaki; Santiago Fraga; Mireille Chinain; Jorge Diogène
Journal:  Mar Drugs       Date:  2010-06-14       Impact factor: 5.118

2.  Reductive Amination for LC-MS Signal Enhancement and Confirmation of the Presence of Caribbean Ciguatoxin-1 in Fish.

Authors:  Fedor Kryuchkov; Alison Robertson; Elizabeth M Mudge; Christopher O Miles; Soetkien Van Gothem; Silvio Uhlig
Journal:  Toxins (Basel)       Date:  2022-06-09       Impact factor: 5.075

3.  Maitotoxin-4, a Novel MTX Analog Produced by Gambierdiscus excentricus.

Authors:  Francesco Pisapia; Manoëlla Sibat; Christine Herrenknecht; Korian Lhaute; Greta Gaiani; Pierre-Jean Ferron; Valérie Fessard; Santiago Fraga; Silvia M Nascimento; R Wayne Litaker; William C Holland; Catherine Roullier; Philipp Hess
Journal:  Mar Drugs       Date:  2017-07-11       Impact factor: 5.118

4.  Identification of New CTX Analogues in Fish from the Madeira and Selvagens Archipelagos by Neuro-2a CBA and LC-HRMS.

Authors:  Àngels Tudó; Maria Rambla-Alegre; Cintia Flores; Núria Sagristà; Paloma Aguayo; Laia Reverté; Mònica Campàs; Neide Gouveia; Carolina Santos; Karl B Andree; Antonio Marques; Josep Caixach; Jorge Diogène
Journal:  Mar Drugs       Date:  2022-03-29       Impact factor: 6.085

5.  Cytotoxic and Hemolytic Activities of Extracts of the Fish Parasite Dinoflagellate Amyloodinium ocellatum.

Authors:  Márcio Moreira; Lucía Soliño; Cátia L Marques; Vincent Laizé; Pedro Pousão-Ferreira; Pedro Reis Costa; Florbela Soares
Journal:  Toxins (Basel)       Date:  2022-07-08       Impact factor: 5.075

6.  Genetic diversity and distribution of the ciguatera-causing dinoflagellate Gambierdiscus spp. (Dinophyceae) in coastal areas of Japan.

Authors:  Tomohiro Nishimura; Shinya Sato; Wittaya Tawong; Hiroshi Sakanari; Keita Uehara; Md Mahfuzur Rahman Shah; Shoichiro Suda; Takeshi Yasumoto; Yohsuke Taira; Haruo Yamaguchi; Masao Adachi
Journal:  PLoS One       Date:  2013-04-11       Impact factor: 3.240

7.  Further advance of Gambierdiscus Species in the Canary Islands, with the First Report of Gambierdiscus belizeanus.

Authors:  Àngels Tudó; Greta Gaiani; Maria Rey Varela; Takeshi Tsumuraya; Karl B Andree; Margarita Fernández-Tejedor; Mònica Campàs; Jorge Diogène
Journal:  Toxins (Basel)       Date:  2020-10-31       Impact factor: 4.546
  7 in total

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