Literature DB >> 20331533

Emerging roles of Ruk/CIN85 in vesicle-mediated transport, adhesion, migration and malignancy.

Serhiy Havrylov1, Maria Jolanta Redowicz, Vladimir L Buchman.   

Abstract

Ruk/CIN85 is an adaptor protein. Similar to many other proteins of this type, Ruk/CIN85 is known to take part in multiple cellular processes including signal transduction, vesicle-mediated transport, cytoskeleton remodelling, programmed cell death and viral infection. Recent studies have also revealed the potential importance of Ruk/CIN85 in cancer cell invasiveness. In this review we summarize the various roles of this protein as well as the potential contribution of Ruk/CIN85 to malignancy and the invasiveness of cancer cells. In the last section of the paper we also speculate on the utility of Ruk/CIN85 as a target for novel anti-cancer therapies.

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Year:  2010        PMID： 20331533     DOI： 10.1111/j.1600-0854.2010.01061.x

Source DB:  PubMed          Journal:  Traffic        ISSN： 1398-9219            Impact factor:   6.215


  20 in total

1.  CD2AP regulates SUMOylation of CIN85 in podocytes.

Authors:  Irini Tossidou; Rainer Niedenthal; Malte Klaus; Beina Teng; Kirstin Worthmann; Benjamin L King; Kevin J Peterson; Hermann Haller; Mario Schiffer
Journal:  Mol Cell Biol       Date:  2011-12-27       Impact factor: 4.272

Review 2.  Pathobiological implications of mucin glycans in cancer: Sweet poison and novel targets.

Authors:  Seema Chugh; Vinayaga S Gnanapragassam; Maneesh Jain; Satyanarayana Rachagani; Moorthy P Ponnusamy; Surinder K Batra
Journal:  Biochim Biophys Acta       Date:  2015-08-28

3.  Gonad Transcriptome Analysis of the Pacific Oyster Crassostrea gigas Identifies Potential Genes Regulating the Sex Determination and Differentiation Process.

Authors:  Chenyang Yue; Qi Li; Hong Yu
Journal:  Mar Biotechnol (NY)       Date:  2018-03-08       Impact factor: 3.619

4.  Novel Host Proteins and Signaling Pathways in Enteropathogenic E. coli Pathogenesis Identified by Global Phosphoproteome Analysis.

Authors:  Roland Scholz; Koshi Imami; Nichollas E Scott; William S Trimble; Leonard J Foster; B Brett Finlay
Journal:  Mol Cell Proteomics       Date:  2015-05-05       Impact factor: 5.911

5.  CIN85 modulates the down-regulation of Fc gammaRIIa expression and function by c-Cbl in a PKC-dependent manner in human neutrophils.

Authors:  Louis Marois; Myriam Vaillancourt; Guillaume Paré; Valérie Gagné; Maria J G Fernandes; Emmanuelle Rollet-Labelle; Paul H Naccache
Journal:  J Biol Chem       Date:  2011-03-03       Impact factor: 5.157

6.  A Dyn2-CIN85 complex mediates degradative traffic of the EGFR by regulation of late endosomal budding.

Authors:  Barbara Schroeder; Shaun G Weller; Jing Chen; Daniel Billadeau; Mark A McNiven
Journal:  EMBO J       Date:  2010-08-13       Impact factor: 11.598

7.  A Novel Interaction of the Catalytic Subunit of Protein Phosphatase 2A with the Adaptor Protein CIN85 Suppresses Phosphatase Activity and Facilitates Platelet Outside-in αIIbβ3 Integrin Signaling.

Authors:  Tanvir Khatlani; Subhashree Pradhan; Qi Da; Tanner Shaw; Vladimir L Buchman; Miguel A Cruz; K Vinod Vijayan
Journal:  J Biol Chem       Date:  2016-06-22       Impact factor: 5.157

8.  Human Cytomegalovirus UL135 Interacts with Host Adaptor Proteins To Regulate Epidermal Growth Factor Receptor and Reactivation from Latency.

Authors:  Michael A Rak; Jason Buehler; Sebastian Zeltzer; Justin Reitsma; Belen Molina; Scott Terhune; Felicia Goodrum
Journal:  J Virol       Date:  2018-09-26       Impact factor: 5.103

9.  Dab1 stabilizes its interaction with Cin85 by suppressing Cin85 phosphorylation at serine 587.

Authors:  Bior K Bior; Bryan A Ballif
Journal:  FEBS Lett       Date:  2012-11-21       Impact factor: 4.124

Review 10.  Membrane trafficking in podocyte health and disease.

Authors:  Agnieszka Swiatecka-Urban
Journal:  Pediatr Nephrol       Date:  2012-08-30       Impact factor: 3.714
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