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Literature DB >> 2031842

Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney.

K Yoshioka¹, T Takemura, M Kanasaki, N Akano, S Maki.

Abstract

Infiltrating cells were analysed in renal biopsy tissue obtained from a 15-year-old girl with acute interstitial nephritis and uveitis using monoclonal antibodies specific for mononuclear cell surface markers. The interstitial infiltrates consisted mainly of T cells and monocytes/macrophages. A considerable proportion of the infiltrating cells were identified by a monoclonal antibody against the interleukin-2 receptor, indicating that a majority of those immune cells are activated. This observation documents the participation of cell-mediated immune injury in interstitial nephritis associated with uveitis.

Entities: Disease Species

Mesh：

Substances：
Receptors, Interleukin-2

Year: 1991 PMID： 2031842 DOI： 10.1007/bf01095961

Source DB: PubMed Journal: Pediatr Nephrol ISSN： 0931-041X Impact factor: 3.714

10 in total

1. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome.

Authors: R S Dobrin; R L Vernier; A L Fish
Journal: Am J Med Date: 1975-09 Impact factor: 4.965

2. Interstitial and glomerular immune cell populations in idiopathic nephrotic syndrome.

Authors: K Nagata; J L Platt; A F Michael
Journal: Kidney Int Date: 1984-01 Impact factor: 10.612

3. Immunohistochemical studies of reflux nephropathy. The role of extracellular matrix, membrane attack complex, and immune cells in glomerular sclerosis.

Authors: K Yoshioka; T Takemura; K Matsubara; H Miyamoto; N Akano; S Maki
Journal: Am J Pathol Date: 1987-11 Impact factor: 4.307

4. Characterization of tubular basement membrane antigens in human kidney.

Authors: K Yoshioka; Y Morimoto; T Iseki; S Maki
Journal: J Immunol Date: 1986-03-01 Impact factor: 5.422

Review 5. Interleukin-2: inception, impact, and implications.

Authors: K A Smith
Journal: Science Date: 1988-05-27 Impact factor: 47.728

6. Neoantigen of the polymerized ninth component of complement. Characterization of a monoclonal antibody and immunohistochemical localization in renal disease.

Authors: R J Falk; A P Dalmasso; Y Kim; C H Tsai; J I Scheinman; H Gewurz; A F Michael
Journal: J Clin Invest Date: 1983-08 Impact factor: 14.808

7. Interstitial nephritis associated with cytomegalovirus infection.

Authors: J L Platt; R K Sibley; A F Michael
Journal: Kidney Int Date: 1985-09 Impact factor: 10.612

8. Immunohistochemical study of Ia antigen in the normal and diseased human kidney.

Authors: N Hinglais; M D Kazatchkine; D J Charron; M D Appay; C Mandet; M Paing; J Bariety
Journal: Kidney Int Date: 1984-03 Impact factor: 10.612

9. Monocyte infiltration and cross-linked fibrin deposition in IgA nephritis and Henoch-Schoenlein purpura nephritis.

Authors: K Yoshioka; T Takemura; N Aya; N Akano; H Miyamoto; S Maki
Journal: Clin Nephrol Date: 1989-09 Impact factor: 0.975

10. Interstitial mononuclear cell populations in renal graft rejection. Identification by monoclonal antibodies in tissue sections.

Authors: J L Platt; T W LeBien; A F Michael
Journal: J Exp Med Date: 1982-01-01 Impact factor: 14.307

10 in total

14 in total

Review 9. Tubulointerstitial nephritis.

Authors: C L Jones; A A Eddy
Journal: Pediatr Nephrol Date: 1992-11 Impact factor: 3.714

10. Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi's syndrome.

Authors: T Igarashi; H Kawato; S Kamoshita; K Nosaka; K Seiya; H Hayakawa
Journal: Pediatr Nephrol Date: 1992-11 Impact factor: 3.714

Acute interstitial nephritis and uveitis syndrome: activated immune cell infiltration in the kidney.

1. Acute eosinophilic interstitial nephritis and renal failure with bone marrow-lymph node granulomas and anterior uveitis. A new syndrome.

2. Interstitial and glomerular immune cell populations in idiopathic nephrotic syndrome.

3. Immunohistochemical studies of reflux nephropathy. The role of extracellular matrix, membrane attack complex, and immune cells in glomerular sclerosis.

4. Characterization of tubular basement membrane antigens in human kidney.

Review 5. Interleukin-2: inception, impact, and implications.

6. Neoantigen of the polymerized ninth component of complement. Characterization of a monoclonal antibody and immunohistochemical localization in renal disease.

7. Interstitial nephritis associated with cytomegalovirus infection.

8. Immunohistochemical study of Ia antigen in the normal and diseased human kidney.

9. Monocyte infiltration and cross-linked fibrin deposition in IgA nephritis and Henoch-Schoenlein purpura nephritis.

10. Interstitial mononuclear cell populations in renal graft rejection. Identification by monoclonal antibodies in tissue sections.

1. A case of tubulointerstitial nephritis and uveitis syndrome with severe immunologic dysregulation.

Review 2. Tubulointerstitial nephritis and uveitis.

3. Modified C-reactive protein might be a target autoantigen of TINU syndrome.

Review 4. Acute tubulointerstitial nephritis occurring with 1-year lapse in identical twins.

5. Tubulointerstitial nephritis and uveitis syndrome with transient hyperthyroidism in an elderly patient.

6. Tubulointerstitial nephritis and uveitis (TINU) syndrome caused by the Chinese herb "Goreisan".

7. Serial renal biopsies in three girls with tubulointerstitial nephritis and uveitis syndrome.

8. A syndrome of acute interstitial nephritis and anterior uveitis.

Review 9. Tubulointerstitial nephritis.

10. Acute tubulointerstitial nephritis with uveitis syndrome presenting as multiple tubular dysfunction including Fanconi's syndrome.