Literature DB >> 20309696

[The role of TNF-alpha as pain mediator].

H-G Schaible1.   

Abstract

Tumor necrosis factor (TNF)-alpha is not only a proinflammatory mediator but also a pain mediator. Numerous nociceptors express the TNF receptors 1 and 2. By a direct action at the nociceptor TNF-alpha is involved in the generation and maintenance of inflammation-related pain.

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Year:  2010        PMID： 20309696     DOI： 10.1007/s00393-010-0619-z

Source DB:  PubMed          Journal:  Z Rheumatol        ISSN： 0340-1855            Impact factor:   1.372


  6 in total

Review 1.  [The capsaicin receptor. "TRPing" transduction for painful stimuli].

Authors:  W Greffrath
Journal:  Schmerz       Date:  2006-06       Impact factor: 1.107

Review 2.  Mode of action of cytokines on nociceptive neurons.

Authors:  Nurcan Uçeyler; Maria Schäfers; Claudia Sommer
Journal:  Exp Brain Res       Date:  2009-03-17       Impact factor: 1.972

3.  Experimental arthritis causes tumor necrosis factor-alpha-dependent infiltration of macrophages into rat dorsal root ganglia which correlates with pain-related behavior.

Authors:  Gisela Segond von Banchet; Michael K Boettger; Nadja Fischer; Mieczyslaw Gajda; Rolf Bräuer; Hans-Georg Schaible
Journal:  Pain       Date:  2009-06-26       Impact factor: 6.961

Review 4.  The role of proinflammatory cytokines in the generation and maintenance of joint pain.

Authors:  H-G Schaible; G Segond von Banchet; M K Boettger; R Bräuer; M Gajda; F Richter; S Hensellek; D Brenn; G Natura
Journal:  Ann N Y Acad Sci       Date:  2010-04       Impact factor: 5.691

5.  Antinociceptive effects of tumor necrosis factor alpha neutralization in a rat model of antigen-induced arthritis: evidence of a neuronal target.

Authors:  Michael K Boettger; Susanne Hensellek; Frank Richter; Mieczyslaw Gajda; Renate Stöckigt; Gisela Segond von Banchet; Rolf Bräuer; Hans-Georg Schaible
Journal:  Arthritis Rheum       Date:  2008-08

6.  The cytokine TNFalpha increases the proportion of DRG neurones expressing the TRPV1 receptor via the TNFR1 receptor and ERK activation.

Authors:  Susanne Hensellek; Patrice Brell; Hans-Georg Schaible; Rolf Bräuer; Gisela Segond von Banchet
Journal:  Mol Cell Neurosci       Date:  2007-08-01       Impact factor: 4.314
  6 in total
  4 in total

Review 1.  [Mirror therapy for inflammatory rheumatic pain: Potentials and limitations].

Authors:  R Bekrater-Bodmann
Journal:  Z Rheumatol       Date:  2015-11       Impact factor: 1.372

Review 2.  Stem cells for the treatment of musculoskeletal pain.

Authors:  Luminita Labusca; Florin Zugun-Eloae; Kaveh Mashayekhi
Journal:  World J Stem Cells       Date:  2015-01-26       Impact factor: 5.326

3.  Conditional TNF-α Overexpression in the Tooth and Alveolar Bone Results in Painful Pulpitis and Osteitis.

Authors:  B E Hall; L Zhang; Z J Sun; E Utreras; M Prochazkova; A Cho; A Terse; P Arany; J C Dolan; B L Schmidt; A B Kulkarni
Journal:  J Dent Res       Date:  2015-10-26       Impact factor: 6.116

4.  Bilateral muscle fiber and nerve influences by TNF-alpha in response to unilateral muscle overuse - studies on TNF receptor expressions.

Authors:  Lina Renström; Per Stål; Yafeng Song; Sture Forsgren
Journal:  BMC Musculoskelet Disord       Date:  2017-11-28       Impact factor: 2.362
  4 in total

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