Literature DB >> 20309476

Diastereoselective HOTf-catalyzed three-component one-pot 1,3-dipolar cycloaddition of alpha-diazo ester, nitrosobenzene and electron-deficient alkene.

Zhen-Jiang Xu1, Di Zhu, Xiaofei Zeng, Fei Wang, Bin Tan, Yuxuan Hou, Yunbo Lv, Guofu Zhong.   

Abstract

A novel HOTf-catalyzed three-component one-pot cycloaddition of alpha-diazo ester, nitrosobenzene and electron deficient alkene has been developed. This catalysis is very simple to operate and tolerant to moisture/oxygen to afford the product with high to excellent diastereoselectivity in good to excellent yield, thus providing a useful and convenient method for the preparation of diverse functionalized isoxazolidines under very mild conditions.

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Year:  2010        PMID： 20309476     DOI： 10.1039/b924575h

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  3 in total

1.  Organocatalytic multicomponent reaction for the acquisition of a selective inhibitor of mPTPB, a virulence factor of tuberculosis.

Authors:  Rongjun He; Li-Fan Zeng; Yantao He; Li Wu; Andrea Michelle Gunawan; Zhong-Yin Zhang
Journal:  Chem Commun (Camb)       Date:  2013-03-11       Impact factor: 6.222

2.  Synthesis of trifluoromethylated isoxazolidines: 1,3-dipolar cycloaddition of nitrosoarenes, (trifluoromethyl)diazomethane, and alkenes.

Authors:  Gary A Molander; Livia N Cavalcanti
Journal:  Org Lett       Date:  2013-06-11       Impact factor: 6.005

3.  Synthesis of spirocyclic Δ4-isoxazolines via [3 + 2] cycloaddition of indanone-derived ketonitrones with alkynes.

Authors:  Yilin Liu; Jiaxue Liu; Yan-Yun Liu; Boxiao Tang; Hongwei Lin; Yuanxiang Li; Lin Zhang
Journal:  RSC Adv       Date:  2021-09-13       Impact factor: 3.361
  3 in total

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