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Literature DB >> 20309010

Dendritic cells and humoral immunity in humans.

Hideki Ueno¹, Nathalie Schmitt, A Karolina Palucka, Jacques Banchereau.

Abstract

Dendritic cells (DCs) orchestrate the innate and adaptive immune systems to induce tolerance and immunity. DC plasticity and subsets are prominent determinants in the regulation of immune responses. Our recent studies suggest that humoral and cellular immunity is regulated by different myeloid DC subsets with distinct intrinsic properties in humans. Although antibody response is preferentially mediated by CD14(+) dermal DCs, cytotoxic T-cell response is preferentially mediated by Langerhans cells (LCs). Thus, mechanisms whereby DCs induce humoral and cellular immunity seem to be fundamentally distinct. In this review, we will focus on the role of DCs in the development of humoral immunity. We will also discuss the mechanisms whereby DCs induce CD4(+) T cells associated with aiding B-cell response, including T follicular helper (Tfh) cells, and why human LCs lack this ability.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2010 PMID： 20309010 PMCID： PMC2865578 DOI： 10.1038/icb.2010.28

Source DB: PubMed Journal: Immunol Cell Biol ISSN： 0818-9641 Impact factor: 5.126

75 in total

1. Loss of TLR2, TLR4, and TLR5 on Langerhans cells abolishes bacterial recognition.

Authors: Angelic M G van der Aar; Regien M R Sylva-Steenland; Jan D Bos; Martien L Kapsenberg; Esther C de Jong; Marcel B M Teunissen
Journal: J Immunol Date: 2007-02-15 Impact factor: 5.422

2. Role of CXCR5 and CCR7 in follicular Th cell positioning and appearance of a programmed cell death gene-1high germinal center-associated subpopulation.

Authors: Nicole M Haynes; Christopher D C Allen; Robin Lesley; K Mark Ansel; Nigel Killeen; Jason G Cyster
Journal: J Immunol Date: 2007-10-15 Impact factor: 5.422

3. Essential role of IL-21 in B cell activation, expansion, and plasma cell generation during CD4+ T cell-B cell collaboration.

Authors: Stefan Kuchen; Rachel Robbins; Gary P Sims; Chen Sheng; Terence M Phillips; Peter E Lipsky; Rachel Ettinger
Journal: J Immunol Date: 2007-11-01 Impact factor: 5.422

Review 4. Germinal-center organization and cellular dynamics.

Authors: Christopher D C Allen; Takaharu Okada; Jason G Cyster
Journal: Immunity Date: 2007-08 Impact factor: 31.745

Review 5. Taking dendritic cells into medicine.

Authors: Ralph M Steinman; Jacques Banchereau
Journal: Nature Date: 2007-09-27 Impact factor: 49.962

6. IL-21 is produced by Th17 cells and drives IL-17 production in a STAT3-dependent manner.

Authors: Lai Wei; Arian Laurence; Kevin M Elias; John J O'Shea
Journal: J Biol Chem Date: 2007-09-20 Impact factor: 5.157

7. Normal human dermis contains distinct populations of CD11c+BDCA-1+ dendritic cells and CD163+FXIIIA+ macrophages.

Authors: Lisa C Zaba; Judilyn Fuentes-Duculan; Ralph M Steinman; James G Krueger; Michelle A Lowes
Journal: J Clin Invest Date: 2007-09 Impact factor: 14.808

8. Essential autocrine regulation by IL-21 in the generation of inflammatory T cells.

Authors: Roza Nurieva; Xuexian O Yang; Gustavo Martinez; Yongliang Zhang; Athanasia D Panopoulos; Li Ma; Kimberly Schluns; Qiang Tian; Stephanie S Watowich; Anton M Jetten; Chen Dong
Journal: Nature Date: 2007-06-20 Impact factor: 49.962

9. IL-21 initiates an alternative pathway to induce proinflammatory T(H)17 cells.

Authors: Thomas Korn; Estelle Bettelli; Wenda Gao; Amit Awasthi; Anneli Jäger; Terry B Strom; Mohamed Oukka; Vijay K Kuchroo
Journal: Nature Date: 2007-06-20 Impact factor: 49.962

10. IL-6 programs T(H)-17 cell differentiation by promoting sequential engagement of the IL-21 and IL-23 pathways.

Authors: Liang Zhou; Ivaylo I Ivanov; Rosanne Spolski; Roy Min; Kevin Shenderov; Takeshi Egawa; David E Levy; Warren J Leonard; Dan R Littman
Journal: Nat Immunol Date: 2007-06-20 Impact factor: 25.606

23 in total

1. Human monocytes are severely impaired in base and DNA double-strand break repair that renders them vulnerable to oxidative stress.

Authors: Martina Bauer; Michael Goldstein; Markus Christmann; Huong Becker; Daniel Heylmann; Bernd Kaina
Journal: Proc Natl Acad Sci U S A Date: 2011-12-12 Impact factor: 11.205

2. A helping hand from neutrophils in T cell-independent antibody responses?

Authors: Stuart G Tangye; Robert Brink
Journal: Nat Immunol Date: 2012-01-19 Impact factor: 25.606

3. The Langerhans cell controversy: are they immunostimulatory or immunoregulatory cells of the skin immune system?

Authors: Patrizia Stoitzner
Journal: Immunol Cell Biol Date: 2010 May-Jun Impact factor: 5.126

Review 4. Myeloid Populations in Systemic Autoimmune Diseases.

Authors: María Morell; Nieves Varela; Concepción Marañón
Journal: Clin Rev Allergy Immunol Date: 2017-10 Impact factor: 8.667

Review 5. In vivo delivery of nucleic acid-formulated microparticles as a potential tolerogenic vaccine for type 1 diabetes.

Authors: Valentina Di Caro; Nick Giannoukakis; Massimo Trucco
Journal: Rev Diabet Stud Date: 2012-12-28

Review 6. Targeting of antigens to skin dendritic cells: possibilities to enhance vaccine efficacy.

Authors: Nikolaus Romani; Martin Thurnher; Juliana Idoyaga; Ralph M Steinman; Vincent Flacher
Journal: Immunol Cell Biol Date: 2010-04-06 Impact factor: 5.126

7. Human tonsil B-cell lymphoma 6 (BCL6)-expressing CD4+ T-cell subset specialized for B-cell help outside germinal centers.

Authors: Salah-Eddine Bentebibel; Nathalie Schmitt; Jacques Banchereau; Hideki Ueno
Journal: Proc Natl Acad Sci U S A Date: 2011-08-01 Impact factor: 11.205