| Literature DB >> 20308542 |
Marjo de Graauw1, Martine H van Miltenburg, Marjanka K Schmidt, Chantal Pont, Reshma Lalai, Joelle Kartopawiro, Evangelia Pardali, Sylvia E Le Dévédec, Vincent T Smit, Annemieke van der Wal, Laura J Van't Veer, Anne-Marie Cleton-Jansen, Peter ten Dijke, Bob van de Water.
Abstract
Annexin A1 (AnxA1) is a candidate regulator of the epithelial- to mesenchymal (EMT)-like phenotypic switch, a pivotal event in breast cancer progression. We show here that AnxA1 expression is associated with a highly invasive basal-like breast cancer subtype both in a panel of human breast cancer cell lines as in breast cancer patients and that AnxA1 is functionally related to breast cancer progression. AnxA1 knockdown in invasive basal-like breast cancer cells reduced the number of spontaneous lung metastasis, whereas additional expression of AnxA1 enhanced metastatic spread. AnxA1 promotes metastasis formation by enhancing TGFbeta/Smad signaling and actin reorganization, which facilitates an EMT-like switch, thereby allowing efficient cell migration and invasion of metastatic breast cancer cells.Entities:
Mesh：
Substances：
Year: 2010 PMID： 20308542 PMCID： PMC2852023 DOI： 10.1073/pnas.0913360107
Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205