OBJECTIVES: To compare free plasma cortisol (FPC) with salivary and calculated cortisol. DESIGN AND METHODS: FPC, salivary cortisol, free cortisol index (FCI), albumin-derived free cortisol index (FCIalb), Coolen's and Dorin's cortisol were assayed during repeated low-dose ACTH test in healthy women. RESULTS: FPC significantly correlated with its surrogates, the most with FCIalb and salivary cortisol. FPC and salivary cortisol showed the highest method agreement. CONCLUSIONS: FCIalb and salivary cortisol are preferred surrogates of FPC. 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
OBJECTIVES: To compare free plasma cortisol (FPC) with salivary and calculated cortisol. DESIGN AND METHODS: FPC, salivary cortisol, free cortisol index (FCI), albumin-derived free cortisol index (FCIalb), Coolen's and Dorin's cortisol were assayed during repeated low-dose ACTH test in healthy women. RESULTS: FPC significantly correlated with its surrogates, the most with FCIalb and salivary cortisol. FPC and salivary cortisol showed the highest method agreement. CONCLUSIONS: FCIalb and salivary cortisol are preferred surrogates of FPC. 2010 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Authors: Harri Lindholm; Jari Ahlberg; Juha Sinisalo; Christer Hublin; Ari Hirvonen; Markku Partinen; Seppo Sarna; Aslak Savolainen Journal: Sleep Disord Date: 2012-06-18