Formation of unsymmetrical 1,4-enediones via a focusing domino strategy: cross-coupling of 1,3-dicarbonyl compounds and methyl ketones or terminal aryl alkenes.

A highly efficient synthesis of unsymmetrical 1,4-enediones from 1,3-dicarbonyl compounds and methyl ketones or terminal aryl alkenes has been developed via a focusing domino strategy. Simple and readily available starting materials, mild reaction conditions, and a very simple operation are advantages of the reaction, which allow straightforward synthesis of a variety of unsymmetrical 1,4-enediones.