Sung Shine Shim1, Joungho Han. 1. Department of Radiology, Center for Imaging Science, Ewha Medical Center, Ewha Medical Research Institute, Ewha Womans University School of Medicine, Mokdong Hospital, Mok 5-dong, Yangcheon-gu, Seoul, 158-710, Korea. sinisim@ewha.ac.kr
Abstract
OBJECTIVE: The objective of this study was to describe the PET/CT findings of mucin-producing non-small cell lung cancer (NSCLC) and how those findings are associated with pathology. METHODS: A review of all patients with FDG-PET/CT identified 11 patients with histopathologically confirmed mucin-producing NSCLC; 3 mucinous bronchioloalveolar carcinoma (mBAC), 5 mixed-type adenocarcinoma with prominent mucinous BAC pattern (ADENO + mBAC), and 3 mixed-type adenocarcinoma with mucin production (ADENO + MUCIN) in our institute. RESULTS: Among 11 patients, only 2 lesions (18%) evidenced positive PET results for standardized uptake value (SUV) of 3.5 (by ROC analysis) whereas all cases were detected correctly at CT. The mean SUV was 2.0 in the 9 lesions not detected and 2.5 in all cases. The mean SUV of pure mBAC was 1.93, that of mucin-producing adenocarcinoma was 2.69 without a significant difference (p = 0.279). No significant correlations between tumor size or stage and SUV were determined. CONCLUSIONS: PET/CT for SUV is limited in the detection of mucin-producing NSCLC. Therefore, the CT component of PET/CT may allow for significantly improved sensitivity and help to reduce delayed diagnose. The SUV in mBACs were lower than the other types of mucin-producing adenocarcinoma; however, we determined no significant difference to exist between the SUVs of two groups of lung cancer.
OBJECTIVE: The objective of this study was to describe the PET/CT findings of mucin-producing non-small cell lung cancer (NSCLC) and how those findings are associated with pathology. METHODS: A review of all patients with FDG-PET/CT identified 11 patients with histopathologically confirmed mucin-producing NSCLC; 3 mucinous bronchioloalveolar carcinoma (mBAC), 5 mixed-type adenocarcinoma with prominent mucinous BAC pattern (ADENO + mBAC), and 3 mixed-type adenocarcinoma with mucin production (ADENO + MUCIN) in our institute. RESULTS: Among 11 patients, only 2 lesions (18%) evidenced positive PET results for standardized uptake value (SUV) of 3.5 (by ROC analysis) whereas all cases were detected correctly at CT. The mean SUV was 2.0 in the 9 lesions not detected and 2.5 in all cases. The mean SUV of pure mBAC was 1.93, that of mucin-producing adenocarcinoma was 2.69 without a significant difference (p = 0.279). No significant correlations between tumor size or stage and SUV were determined. CONCLUSIONS: PET/CT for SUV is limited in the detection of mucin-producing NSCLC. Therefore, the CT component of PET/CT may allow for significantly improved sensitivity and help to reduce delayed diagnose. The SUV in mBACs were lower than the other types of mucin-producing adenocarcinoma; however, we determined no significant difference to exist between the SUVs of two groups of lung cancer.
Authors: Kyuichi Kadota; Christos Colovos; Kei Suzuki; Nabil P Rizk; Mark P S Dunphy; Emily C Zabor; Camelia S Sima; Akihiko Yoshizawa; William D Travis; Valerie W Rusch; Prasad S Adusumilli Journal: Ann Surg Oncol Date: 2012-05-30 Impact factor: 5.344
Authors: Yi-Chen Yeh; Kyuichi Kadota; Jun-ichi Nitadori; Camelia S Sima; Nabil P Rizk; David R Jones; William D Travis; Prasad S Adusumilli Journal: Eur J Cardiothorac Surg Date: 2015-09-15 Impact factor: 4.191
Authors: Julian M M Rogasch; Ingo G Steffen; Sandra Riedel; Ivayla Apostolova; Heinz Wertzel; H Jost Achenbach; Ferdinand L G A Steinkrüger; Thomas Kalinski; Meinald Schultz; Jens Schreiber; Holger Amthauer; Christian Furth Journal: Eur Radiol Date: 2015-11-11 Impact factor: 5.315
Authors: Felipe Alves Mourato; Ana Emília Teixeira Brito; Monique Sampaio Cruz Romão; Renata Guerra Galvão Santos; Cristiana Altino de Almeida; Paulo José de Almeida Filho; Aline Lopes Garcia Leal Journal: Radiol Bras Date: 2020 Jan-Feb