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Literature DB >> 20305826

Role of infection in the development and exacerbation of asthma.

Abstract

Respiratory infections are associated with wheezing illnesses in all ages and may also impact the development and severity of asthma. Respiratory tract infections caused by viruses, Chlamydophila or Mycoplasma have been hypothesized to have significant roles in the pathogenesis of asthma. Progress is being made toward establishing the mechanisms by which these agents can cause acute wheezing and impact the pathophysiology of asthma. Host factors probably contribute to the risk of asthma inception and exacerbation, and these contributions may also vary with respect to early- versus adult-onset disease. This review discusses these various associations as they pertain to the development and exacerbation of asthma.

Entities: Chemical Disease Gene Species

Keywords: asthma; asthma inception; exacerbation; respiratory infection; virus

Mesh：

Year: 2010 PMID： 20305826 PMCID： PMC2840256 DOI： 10.1586/ers.09.60

Source DB: PubMed Journal: Expert Rev Respir Med ISSN： 1747-6348 Impact factor: 3.772

171 in total

1. Chronic Chlamydia pneumoniae infection and asthma exacerbations in children.

Authors: A F Cunningham; S L Johnston; S A Julious; F C Lampe; M E Ward
Journal: Eur Respir J Date: 1998-02 Impact factor: 16.671

2. Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects.

Authors: J E Gern; W Calhoun; C Swenson; G Shen; W W Busse
Journal: Am J Respir Crit Care Med Date: 1997-06 Impact factor: 21.405

3. Association of radiologically ascertained pneumonia before age 3 yr with asthmalike symptoms and pulmonary function during childhood: a prospective study.

Authors: J A Castro-Rodríguez; C J Holberg; A L Wright; M Halonen; L M Taussig; W J Morgan; F D Martinez
Journal: Am J Respir Crit Care Med Date: 1999-06 Impact factor: 21.405

4. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses.

Authors: G P Rakes; E Arruda; J M Ingram; G E Hoover; J C Zambrano; F G Hayden; T A Platts-Mills; P W Heymann
Journal: Am J Respir Crit Care Med Date: 1999-03 Impact factor: 21.405

5. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma.

Authors: M Kraft; G H Cassell; J E Henson; H Watson; J Williamson; B P Marmion; C A Gaydos; R J Martin
Journal: Am J Respir Crit Care Med Date: 1998-09 Impact factor: 21.405

6. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years.

Authors: R T Stein; D Sherrill; W J Morgan; C J Holberg; M Halonen; L M Taussig; A L Wright; F D Martinez
Journal: Lancet Date: 1999-08-14 Impact factor: 79.321

7. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.

Authors: Z Zhu; R J Homer; Z Wang; Q Chen; G P Geba; J Wang; Y Zhang; J A Elias
Journal: J Clin Invest Date: 1999-03 Impact factor: 14.808

8. Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children.

Authors: L Muhe; S Lulseged; K E Mason; E A Simoes
Journal: Lancet Date: 1997-06-21 Impact factor: 79.321

9. Detection of rhinovirus RNA in lower airway cells during experimentally induced infection.

Authors: J E Gern; D M Galagan; N N Jarjour; E C Dick; W W Busse
Journal: Am J Respir Crit Care Med Date: 1997-03 Impact factor: 21.405

10. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma.

Authors: Benjamin A Raby; Ross Lazarus; Edwin K Silverman; Steven Lake; Christoph Lange; Mathias Wjst; Scott T Weiss
Journal: Am J Respir Crit Care Med Date: 2004-07-28 Impact factor: 21.405

21 in total

1. Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation.

Authors: Loren C Denlinger; Ron L Sorkness; Wai-Ming Lee; Michael D Evans; Michele J Wolff; Sameer K Mathur; Gina M Crisafi; Katie L Gaworski; Tressa E Pappas; Rose F Vrtis; Elizabeth A Kelly; James E Gern; Nizar N Jarjour
Journal: Am J Respir Crit Care Med Date: 2011-11-01 Impact factor: 21.405

10. The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms.

Authors: Katir K Patel; Erica Anderson; Paul S Salva; Wilmore C Webley
Journal: Respir Res Date: 2012-04-18

Role of infection in the development and exacerbation of asthma.

1. Chronic Chlamydia pneumoniae infection and asthma exacerbations in children.

2. Rhinovirus infection preferentially increases lower airway responsiveness in allergic subjects.

3. Association of radiologically ascertained pneumonia before age 3 yr with asthmalike symptoms and pulmonary function during childhood: a prospective study.

4. Rhinovirus and respiratory syncytial virus in wheezing children requiring emergency care. IgE and eosinophil analyses.

5. Detection of Mycoplasma pneumoniae in the airways of adults with chronic asthma.

6. Respiratory syncytial virus in early life and risk of wheeze and allergy by age 13 years.

7. Pulmonary expression of interleukin-13 causes inflammation, mucus hypersecretion, subepithelial fibrosis, physiologic abnormalities, and eotaxin production.

8. Case-control study of the role of nutritional rickets in the risk of developing pneumonia in Ethiopian children.

9. Detection of rhinovirus RNA in lower airway cells during experimentally induced infection.

10. Association of vitamin D receptor gene polymorphisms with childhood and adult asthma.

1. Lower airway rhinovirus burden and the seasonal risk of asthma exacerbation.

Review 2. Infection in severe asthma exacerbations and critical asthma syndrome.

Review 3. The Regulatory Function of Eosinophils.

4. Protection from asthma in a high-risk birth cohort by attenuated P2X(7) function.

5. NLRP3 Is a Critical Regulator of Inflammation and Innate Immune Cell Response during Mycoplasma pneumoniae Infection.

Review 6. Asthma and the host-microbe interaction.

7. Macrolides for Acute Wheezing Episodes in Preschool Children.

8. The Human Microbiome and Public Health: Social and Ethical Considerations.

9. In young children, persistent wheezing is associated with bronchial bacterial infection: a retrospective analysis.

10. The prevalence and identity of Chlamydia-specific IgE in children with asthma and other chronic respiratory symptoms.