Literature DB >> 20305648

Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease.

Martin Fuhrmann1, Tobias Bittner, Christian K E Jung, Steffen Burgold, Richard M Page, Gerda Mitteregger, Christian Haass, Frank M LaFerla, Hans Kretzschmar, Jochen Herms.   

Abstract

Microglia, the immune cells of the brain, can have a beneficial effect in Alzheimer's disease by phagocytosing amyloid-beta. Two-photon in vivo imaging of neuron loss in the intact brain of living Alzheimer's disease mice revealed an involvement of microglia in neuron elimination, indicated by locally increased number and migration velocity of microglia around lost neurons. Knockout of the microglial chemokine receptor Cx3cr1, which is critical in neuron-microglia communication, prevented neuron loss.

Entities:  

Mesh：

Substances：

Year:  2010        PMID： 20305648      PMCID： PMC4072212          DOI： 10.1038/nn.2511

Source DB:  PubMed          Journal:  Nat Neurosci        ISSN： 1097-6256            Impact factor:   24.884


  15 in total

1.  Triple-transgenic model of Alzheimer's disease with plaques and tangles: intracellular Abeta and synaptic dysfunction.

Authors:  Salvatore Oddo; Antonella Caccamo; Jason D Shepherd; M Paul Murphy; Todd E Golde; Rakez Kayed; Raju Metherate; Mark P Mattson; Yama Akbari; Frank M LaFerla
Journal:  Neuron       Date:  2003-07-31       Impact factor: 17.173

2.  Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo.

Authors:  Axel Nimmerjahn; Frank Kirchhoff; Fritjof Helmchen
Journal:  Science       Date:  2005-04-14       Impact factor: 47.728

3.  ATP mediates rapid microglial response to local brain injury in vivo.

Authors:  Dimitrios Davalos; Jaime Grutzendler; Guang Yang; Jiyun V Kim; Yi Zuo; Steffen Jung; Dan R Littman; Michael L Dustin; Wen-Biao Gan
Journal:  Nat Neurosci       Date:  2005-05-15       Impact factor: 24.884

4.  Control of microglial neurotoxicity by the fractalkine receptor.

Authors:  Astrid E Cardona; Erik P Pioro; Margaret E Sasse; Volodymyr Kostenko; Sandra M Cardona; Ineke M Dijkstra; Deren Huang; Grahame Kidd; Stephen Dombrowski; RanJan Dutta; Jar-Chi Lee; Donald N Cook; Steffen Jung; Sergio A Lira; Dan R Littman; Richard M Ransohoff
Journal:  Nat Neurosci       Date:  2006-06-18       Impact factor: 24.884

5.  Analysis of fractalkine receptor CX(3)CR1 function by targeted deletion and green fluorescent protein reporter gene insertion.

Authors:  S Jung; J Aliberti; P Graemmel; M J Sunshine; G W Kreutzberg; A Sher; D R Littman
Journal:  Mol Cell Biol       Date:  2000-06       Impact factor: 4.272

Review 6.  Inflammation in Alzheimer disease: driving force, bystander or beneficial response?

Authors:  Tony Wyss-Coray
Journal:  Nat Med       Date:  2006-09       Impact factor: 53.440

7.  Role for neuronally derived fractalkine in mediating interactions between neurons and CX3CR1-expressing microglia.

Authors:  J K Harrison; Y Jiang; S Chen; Y Xia; D Maciejewski; R K McNamara; W J Streit; M N Salafranca; S Adhikari; D A Thompson; P Botti; K B Bacon; L Feng
Journal:  Proc Natl Acad Sci U S A       Date:  1998-09-01       Impact factor: 11.205

8.  Specific domains of beta-amyloid from Alzheimer plaque elicit neuron killing in human microglia.

Authors:  D Giulian; L J Haverkamp; J H Yu; W Karshin; D Tom; J Li; J Kirkpatrick; L M Kuo; A E Roher
Journal:  J Neurosci       Date:  1996-10-01       Impact factor: 6.167

9.  Formation and maintenance of Alzheimer's disease beta-amyloid plaques in the absence of microglia.

Authors:  Stefan A Grathwohl; Roland E Kälin; Tristan Bolmont; Stefan Prokop; Georg Winkelmann; Stephan A Kaeser; Jörg Odenthal; Rebecca Radde; Therese Eldh; Sam Gandy; Adriano Aguzzi; Matthias Staufenbiel; Paul M Mathews; Hartwig Wolburg; Frank L Heppner; Mathias Jucker
Journal:  Nat Neurosci       Date:  2009-10-18       Impact factor: 24.884

10.  Neurocytopathic effects of beta-amyloid-stimulated monocytes: a potential mechanism for central nervous system damage in Alzheimer disease.

Authors:  J A London; D Biegel; J S Pachter
Journal:  Proc Natl Acad Sci U S A       Date:  1996-04-30       Impact factor: 11.205
View more
  250 in total

1.  Regulation of tau pathology by the microglial fractalkine receptor.

Authors:  Kiran Bhaskar; Megan Konerth; Olga N Kokiko-Cochran; Astrid Cardona; Richard M Ransohoff; Bruce T Lamb
Journal:  Neuron       Date:  2010-10-06       Impact factor: 17.173

2.  The fractalkine receptor but not CCR2 is present on microglia from embryonic development throughout adulthood.

Authors:  Makiko Mizutani; Paula A Pino; Noah Saederup; Israel F Charo; Richard M Ransohoff; Astrid E Cardona
Journal:  J Immunol       Date:  2011-11-11       Impact factor: 5.422

3.  CD45 deficiency drives amyloid-β peptide oligomers and neuronal loss in Alzheimer's disease mice.

Authors:  Yuyan Zhu; Huayan Hou; Kavon Rezai-Zadeh; Brian Giunta; Amanda Ruscin; Carmelina Gemma; Jingji Jin; Natasa Dragicevic; Patrick Bradshaw; Suhail Rasool; Charles G Glabe; Jared Ehrhart; Paula Bickford; Takashi Mori; Demian Obregon; Terrence Town; Jun Tan
Journal:  J Neurosci       Date:  2011-01-26       Impact factor: 6.167

4.  CX3CR1 deficiency leads to impairment of hippocampal cognitive function and synaptic plasticity.

Authors:  Justin T Rogers; Josh M Morganti; Adam D Bachstetter; Charles E Hudson; Melinda M Peters; Bethany A Grimmig; Edwin J Weeber; Paula C Bickford; Carmelina Gemma
Journal:  J Neurosci       Date:  2011-11-09       Impact factor: 6.167

5.  Neuroinflammatory Cytokines-The Common Thread in Alzheimer's Pathogenesis.

Authors:  W Sue T Griffin; Steven W Barger
Journal:  US Neurol       Date:  2010

Review 6.  Microglial cell origin and phenotypes in health and disease.

Authors:  Kaoru Saijo; Christopher K Glass
Journal:  Nat Rev Immunol       Date:  2011-10-25       Impact factor: 53.106

7.  Microglia in the cerebral cortex in autism.

Authors:  Nicole A Tetreault; Atiya Y Hakeem; Sue Jiang; Brian A Williams; Elizabeth Allman; Barbara J Wold; John M Allman
Journal:  J Autism Dev Disord       Date:  2012-12

Review 8.  Microglia in Alzheimer's disease.

Authors:  Heela Sarlus; Michael T Heneka
Journal:  J Clin Invest       Date:  2017-09-01       Impact factor: 14.808

Review 9.  Multitasking Microglia and Alzheimer's Disease: Diversity, Tools and Therapeutic Targets.

Authors:  Alexandra Grubman; Katja M Kanninen; Tarja Malm
Journal:  J Mol Neurosci       Date:  2016-09-22       Impact factor: 3.444

10.  Longitudinal in vivo two-photon fluorescence imaging.

Authors:  Sarah E Crowe; Graham C R Ellis-Davies
Journal:  J Comp Neurol       Date:  2014-06-01       Impact factor: 3.215
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.