PURPOSE OF REVIEW: Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from endothelial precursor cells (EPCs). Current understanding of the role of angiogenesis and vasculogenesis in rheumatoid arthritis (RA) and possibilities of therapeutic intervention should be summarized. RECENT FINDINGS: There have been many recent studies on the role of the hypoxia and hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin axis in angiogenesis associated with RA. The role of additional growth factors, chemokines, cytokines, matrix components and adhesion molecules has been further characterized. Macrophage migration inhibitory factor (MIF) may link inflammation, angiogenesis and atherosclerosis. Junctional adhesion molecules (JAMs) and focal adhesion kinases (FAKs) have recently been implicated in inflammatory angiogenesis. Novel information regarding the role of serum amyloid A (SAA) and sphingosine kinase has become available. Most of these angiogenic factors have recently been targeted using various techniques and arthritis models. Whereas angiogenesis is abundant in RA, there is defective EPC function and vasculogenesis leading to atherosclerosis and vascular disease in arthritis. Treatment with EPCs already under investigation in vascular diseases may also be attempted in RA. SUMMARY: Targeting angiogenesis and restoration of vasculogenesis may be beneficial for the therapy and outcome of RA.
PURPOSE OF REVIEW: Angiogenesis is the formation of new capillaries from pre-existing vessels, whereas vasculogenesis is de-novo capillary formation from endothelial precursor cells (EPCs). Current understanding of the role of angiogenesis and vasculogenesis in rheumatoid arthritis (RA) and possibilities of therapeutic intervention should be summarized. RECENT FINDINGS: There have been many recent studies on the role of the hypoxia and hypoxia-inducible factor (HIF)-vascular endothelial growth factor (VEGF)-angiopoietin axis in angiogenesis associated with RA. The role of additional growth factors, chemokines, cytokines, matrix components and adhesion molecules has been further characterized. Macrophage migration inhibitory factor (MIF) may link inflammation, angiogenesis and atherosclerosis. Junctional adhesion molecules (JAMs) and focal adhesion kinases (FAKs) have recently been implicated in inflammatory angiogenesis. Novel information regarding the role of serum amyloid A (SAA) and sphingosine kinase has become available. Most of these angiogenic factors have recently been targeted using various techniques and arthritis models. Whereas angiogenesis is abundant in RA, there is defective EPC function and vasculogenesis leading to atherosclerosis and vascular disease in arthritis. Treatment with EPCs already under investigation in vascular diseases may also be attempted in RA. SUMMARY: Targeting angiogenesis and restoration of vasculogenesis may be beneficial for the therapy and outcome of RA.
Authors: Hui-Fang Zhou; Grace Hu; Samuel A Wickline; Gregory M Lanza; Christine T N Pham Journal: Nanomedicine (Lond) Date: 2010-09 Impact factor: 5.307
Authors: Ludguier D Montejo; Jingfei Jia; Hyun K Kim; Uwe J Netz; Sabine Blaschke; Gerhard A Müller; Andreas H Hielscher Journal: J Biomed Opt Date: 2013-07 Impact factor: 3.170
Authors: Peter A Knetsch; Milos Petrik; Christoph M Griessinger; Christine Rangger; Melpomeni Fani; Christian Kesenheimer; Elisabeth von Guggenberg; Bernd J Pichler; Irene Virgolini; Clemens Decristoforo; Roland Haubner Journal: Eur J Nucl Med Mol Imaging Date: 2011-04-13 Impact factor: 9.236
Authors: Muhammad Farooq Rai; Hua Pan; Huimin Yan; Linda J Sandell; Christine T N Pham; Samuel A Wickline Journal: Transl Res Date: 2019-07-10 Impact factor: 7.012
Authors: Gönül Gurol; Ihsan Hakkı Ciftci; Halil Harman; Engin Karakece; Ayhan Kamanli; Ibrahim Tekeoglu Journal: Int J Clin Exp Pathol Date: 2015-02-01