Literature DB >> 20304672

Separation of isomers L-alanine and sarcosine in urine by electrospray ionization and tandem differential mobility analysis-mass spectrometry.

Pablo Martínez-Lozano1, Juan Rus.   

Abstract

Sarcosine, an isomer of L-alanine, has been proposed as a prostate cancer progression biomarker [1]. Both compounds are detected in urine, where the measured sarcosine/alanine ratio has been found to be higher in prostate biopsy-positive group versus controls. We present here preliminary evidence showing that urine samples spiked with sarcosine/alanine can be partially resolved in 3 min via tandem differential mobility analysis-mass spectrometry (DMA-MS). Based on the calibration curves obtained for two mobility peaks, we finally estimate their concentration ratio in urine. Copyright 2010 American Society for Mass Spectrometry. Published by Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20304672     DOI： 10.1016/j.jasms.2010.02.021

Source DB:  PubMed          Journal:  J Am Soc Mass Spectrom        ISSN： 1044-0305            Impact factor:   3.109


  4 in total

1.  Tandem ion mobility-mass spectrometry (IMS-MS) study of ion evaporation from ionic liquid-acetonitrile nanodrops.

Authors:  Christopher J Hogan; Juan Fernández de la Mora
Journal:  Phys Chem Chem Phys       Date:  2009-08-14       Impact factor: 3.676

2.  Monitoring dynamic changes in lymph metabolome of fasting and fed rats by electrospray ionization-ion mobility mass spectrometry (ESI-IMMS).

Authors:  Kimberly Kaplan; Prabha Dwivedi; Sean Davidson; Qing Yang; Patrick Tso; William Siems; Herbert H Hill
Journal:  Anal Chem       Date:  2009-10-01       Impact factor: 6.986

3.  Metabolomic profiles delineate potential role for sarcosine in prostate cancer progression.

Authors:  Arun Sreekumar; Laila M Poisson; Thekkelnaycke M Rajendiran; Amjad P Khan; Qi Cao; Jindan Yu; Bharathi Laxman; Rohit Mehra; Robert J Lonigro; Yong Li; Mukesh K Nyati; Aarif Ahsan; Shanker Kalyana-Sundaram; Bo Han; Xuhong Cao; Jaeman Byun; Gilbert S Omenn; Debashis Ghosh; Subramaniam Pennathur; Danny C Alexander; Alvin Berger; Jeffrey R Shuster; John T Wei; Sooryanarayana Varambally; Christopher Beecher; Arul M Chinnaiyan
Journal:  Nature       Date:  2009-02-12       Impact factor: 49.962

4.  Alpha-synuclein: stable compact and extended monomeric structures and pH dependence of dimer formation.

Authors:  Summer L Bernstein; Dengfeng Liu; Thomas Wyttenbach; Michael T Bowers; Jennifer C Lee; Harry B Gray; Jay R Winkler
Journal:  J Am Soc Mass Spectrom       Date:  2004-10       Impact factor: 3.109
  4 in total
  4 in total

1.  The collision cross sections of iodide salt cluster ions in air via differential mobility analysis-mass spectrometry.

Authors:  Hui Ouyang; Carlos Larriba-Andaluz; Derek R Oberreit; Christopher J Hogan
Journal:  J Am Soc Mass Spectrom       Date:  2013-09-12       Impact factor: 3.109

2.  Resolution and Assignment of Differential Ion Mobility Spectra of Sarcosine and Isomers.

Authors:  Francis Berthias; Belkis Maatoug; Gary L Glish; Fathi Moussa; Philippe Maitre
Journal:  J Am Soc Mass Spectrom       Date:  2018-02-21       Impact factor: 3.109

Review 3.  Urine markers and prostate cancer.

Authors:  Jacek Wilkosz; Magdalena Bryś; Waldemar Różański
Journal:  Cent European J Urol       Date:  2011-03-18

4.  Development of sarcosine quantification in urine based on enzyme-coupled colorimetric method for prostate cancer diagnosis.

Authors:  Vichanan Yamkamon; Benjarong Phakdee; Sakda Yainoy; Thummaruk Suksrichawalit; Tararat Tatanandana; Premsant Sangkum; Warawan Eiamphungporn
Journal:  EXCLI J       Date:  2018-05-17       Impact factor: 4.068
  4 in total

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