Literature DB >> 20304655

Antiproliferative activity of synthetic naphthoquinones related to lapachol. First synthesis of 5-hydroxylapachol.

Evelyn L Bonifazi1, Carla Ríos-Luci, Leticia G León, Gerardo Burton, José M Padrón, Rosana I Misico.   

Abstract

A series of 5-hydroxy-1,4-naphthoquinones analogues was synthesized from juglone (6) and their antiproliferative activity against a representative panel of six human solid tumor cell lines has been investigated. The 2,5-dihydroxy-3-(3-methylbut-2-enyl)naphthalene-1,4-dione (4) and 2,3-dihydro-5-hydroxy-2-(prop-1-en-2-yl)naphtho[2,3-b]furan-4,9-dione (27) were the most potent antiproliferative agents with GI(50) values of 0.42-8.1 and 0.80-2.2microM, respectively. The results provide insight into the correlation between some structural properties of 5-hydroxynaphthoquinones and their antiproliferative activity. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20304655     DOI： 10.1016/j.bmc.2010.02.032

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  8 in total

1.  Discovery of 1,4-Naphthoquinones as a New Class of Antiproliferative Agents Targeting GPR55.

Authors:  Mariateresa Badolato; Gabriele Carullo; Maria Cristina Caroleo; Erika Cione; Francesca Aiello; Fabrizio Manetti
Journal:  ACS Med Chem Lett       Date:  2019-02-15       Impact factor: 4.345

2.  Synthesis of benzonaphthofuroquinones and benzoylnaphthindolizinediones by reactions of flavonoids with dichlone under basylous, oxygenous and aqueous conditions: their cytotoxic and apoptotic activities.

Authors:  Peng Luo; Wanxing Wei; Saqlain Haider; Shabana I Khan; Mei Wang; Weigao Pan; Amar G Chittiboyina
Journal:  RSC Adv       Date:  2020-08-04       Impact factor: 4.036

3.  Encapsulation of nor-β-lapachone into poly(d,l)-lactide-co-glycolide (PLGA) microcapsules: full characterization, computational details and cytotoxic activity against human cancer cell lines.

Authors:  Marcília P Costa; Anderson C S Feitosa; Fátima C E Oliveira; Bruno C Cavalcanti; Gleiston G Dias; Ewerton W S Caetano; Francisco A M Sales; Valder N Freire; Stefano Di Fiore; Rainer Fischer; Luiz O Ladeira; Eufrânio N da Silva Júnior; Claudia Pessoa
Journal:  Medchemcomm       Date:  2017-09-07       Impact factor: 3.597

Review 4.  Mannich bases in medicinal chemistry and drug design.

Authors:  Gheorghe Roman
Journal:  Eur J Med Chem       Date:  2014-10-30       Impact factor: 6.514

5.  Quinone-amino acid conjugates targeting Leishmania amino acid transporters.

Authors:  Federica Prati; Adele Goldman-Pinkovich; Federica Lizzi; Federica Belluti; Roni Koren; Dan Zilberstein; Maria Laura Bolognesi
Journal:  PLoS One       Date:  2014-09-25       Impact factor: 3.240

6.  Purification and Characterization of an Active Principle, Lawsone, Responsible for the Plasmid Curing Activity of Plumbago zeylanica Root Extracts.

Authors:  Rajashree Bhalchandra Patwardhan; Prashant Kamalakar Dhakephalkar; Balu Ananda Chopade; Dilip D Dhavale; Ramesh R Bhonde
Journal:  Front Microbiol       Date:  2018-11-08       Impact factor: 5.640

7.  Green Synthesis and Electrochemical Properties of Mono- and Dimers Derived from Phenylaminoisoquinolinequinones.

Authors:  Juana Andrea Ibacache; Jaime A Valderrama; Judith Faúndes; Alex Danimann; Francisco J Recio; César A Zúñiga
Journal:  Molecules       Date:  2019-11-30       Impact factor: 4.411

Review 8.  Nature curing cancer - review on structural modification studies with natural active compounds having anti-tumor efficiency.

Authors:  Gurpreet Kaur; Neelam Verma
Journal:  Biotechnol Rep (Amst)       Date:  2015-01-24
  8 in total

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