| Literature DB >> 20304645 |
Supriya Singh1, Pintu K Mandal, Nagendra Singh, Anup K Misra, Shubhra Singh, Vinita Chaturvedi, Sudhir Sinha, Anil K Saxena.
Abstract
A series of novel substituted hydrazinecarbothioamides was synthesized and evaluated for anti-TB activity. Three most active compounds viz. 1, 6 and 12 were found to exhibit minimum inhibitory concentration (MIC) of 0.4 microg/mL, whereas four compounds viz. 3, 5, 10 and 11 showed comparatively lesser activity with MIC value of 0.8 microg/mL against Mycobacterium tuberculosis strain. A highly significant QSAR equation explaining 81.8% variance is described. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20304645 DOI： 10.1016/j.bmcl.2010.02.081
Source DB: PubMed Journal: Bioorg Med Chem Lett ISSN： 0960-894X Impact factor: 2.823