Literature DB >> 20303881

Anti-inflammatory Agents: Present and Future.

Charles A Dinarello1.   

Abstract

Inflammation involving the innate and adaptive immune systems is a normal response to infection. However, when allowed to continue unchecked, inflammation may result in autoimmune or autoinflammatory disorders, neurodegenerative disease, or cancer. A variety of safe and effective anti-inflammatory agents are available, including aspirin and other nonsteroidal anti-inflammatories, with many more drugs under development. In particular, the new era of anti-inflammatory agents includes "biologicals" such as anticytokine therapies and small molecules that block the activity of kinases. Other anti-inflammatories currently in use or under development include statins, histone deacetylase inhibitors, PPAR agonists, and small RNAs. This Review discusses the current status of anti-inflammatory drug research and the development of new anti-inflammatory therapeutics. 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20303881      PMCID： PMC3752337          DOI： 10.1016/j.cell.2010.02.043

Source DB:  PubMed          Journal:  Cell        ISSN： 0092-8674            Impact factor:   41.582


  105 in total

1.  Phospholipases C and A2 control lysosome-mediated IL-1 beta secretion: Implications for inflammatory processes.

Authors:  Cristina Andrei; Paola Margiocco; Alessandro Poggi; Lavinia V Lotti; M R Torrisi; Anna Rubartelli
Journal:  Proc Natl Acad Sci U S A       Date:  2004-06-10       Impact factor: 11.205

2.  The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the synthesis of interleukin-1 and tumor necrosis factor by mononuclear cells.

Authors:  S Endres; R Ghorbani; V E Kelley; K Georgilis; G Lonnemann; J W van der Meer; J G Cannon; T S Rogers; M S Klempner; P C Weber
Journal:  N Engl J Med       Date:  1989-02-02       Impact factor: 91.245

3.  Affinity-purified human interleukin I is cytotoxic to isolated islets of Langerhans.

Authors:  T Mandrup-Poulsen; K Bendtzen; J Nerup; C A Dinarello; M Svenson; J H Nielsen
Journal:  Diabetologia       Date:  1986-01       Impact factor: 10.122

4.  Statins differ in their ability to block NF-kappaB activation in human blood monocytes.

Authors:  A Hilgendorff; H Muth; B Parviz; A Staubitz; W Haberbosch; H Tillmanns; H Hölschermann
Journal:  Int J Clin Pharmacol Ther       Date:  2003-09       Impact factor: 1.366

5.  Mechanisms of caspase-1 activation by P2X7 receptor-mediated K+ release.

Authors:  J Michelle Kahlenberg; George R Dubyak
Journal:  Am J Physiol Cell Physiol       Date:  2003-12-24       Impact factor: 4.249

6.  Valproic acid reduces brain damage induced by transient focal cerebral ischemia in rats: potential roles of histone deacetylase inhibition and heat shock protein induction.

Authors:  Ming Ren; Yan Leng; MiRa Jeong; Peter R Leeds; De-Maw Chuang
Journal:  J Neurochem       Date:  2004-06       Impact factor: 5.372

7.  Interleukin 1 induces interleukin 1. I. Induction of circulating interleukin 1 in rabbits in vivo and in human mononuclear cells in vitro.

Authors:  C A Dinarello; T Ikejima; S J Warner; S F Orencole; G Lonnemann; J G Cannon; P Libby
Journal:  J Immunol       Date:  1987-09-15       Impact factor: 5.422

8.  Antibodies to cachectin/tumor necrosis factor reduce interleukin 1 beta and interleukin 6 appearance during lethal bacteremia.

Authors:  Y Fong; K J Tracey; L L Moldawer; D G Hesse; K B Manogue; J S Kenney; A T Lee; G C Kuo; A C Allison; S F Lowry
Journal:  J Exp Med       Date:  1989-11-01       Impact factor: 14.307

9.  Suberoylanilide hydroxamic acid, a histone deacetylase inhibitor, ameliorates motor deficits in a mouse model of Huntington's disease.

Authors:  Emma Hockly; Victoria M Richon; Benjamin Woodman; Donna L Smith; Xianbo Zhou; Eddie Rosa; Kirupa Sathasivam; Shabnam Ghazi-Noori; Amarbirpal Mahal; Philip A S Lowden; Joan S Steffan; J Lawrence Marsh; Leslie M Thompson; Cathryn M Lewis; Paul A Marks; Gillian P Bates
Journal:  Proc Natl Acad Sci U S A       Date:  2003-02-07       Impact factor: 11.205

10.  Tumor necrosis factor (cachectin) is an endogenous pyrogen and induces production of interleukin 1.

Authors:  C A Dinarello; J G Cannon; S M Wolff; H A Bernheim; B Beutler; A Cerami; I S Figari; M A Palladino; J V O'Connor
Journal:  J Exp Med       Date:  1986-06-01       Impact factor: 14.307
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  280 in total

1.  Sterile inflammation of endothelial cell-derived apoptotic bodies is mediated by interleukin-1α.

Authors:  Yaël Berda-Haddad; Stéphane Robert; Paul Salers; Leila Zekraoui; Catherine Farnarier; Charles A Dinarello; Françoise Dignat-George; Gilles Kaplanski
Journal:  Proc Natl Acad Sci U S A       Date:  2011-12-05       Impact factor: 11.205

Review 2.  Histone deacetylase inhibitors as therapeutic agents for acute central nervous system injuries.

Authors:  Na'ama A Shein; Esther Shohami
Journal:  Mol Med       Date:  2011-01-25       Impact factor: 6.354

3.  Controlled release of triamcinolone acetonide from polyurethane implantable devices: application for inhibition of inflammatory-angiogenesis.

Authors:  Flávia Carmo Horta Pinto; Armando Da Silva-Cunha Junior; Rodrigo Lambert Oréfice; Eliane Ayres; Silvia Passos Andrade; Luiza Dias C Lima; Sandra A Lima Moura; Gisele Rodrigues Da Silva
Journal:  J Mater Sci Mater Med       Date:  2012-04-01       Impact factor: 3.896

4.  Interleukin-1R signaling is essential for induction of proapoptotic CD8 T cells, viral clearance, and pathology during lymphocytic choriomeningitis virus infection in mice.

Authors:  Lars T Joeckel; Reinhard Wallich; Sunil S Metkar; Christopher J Froelich; Markus M Simon; Christoph Borner
Journal:  J Virol       Date:  2012-06-06       Impact factor: 5.103

Review 5.  Novel lipid mediators promote resolution of acute inflammation: impact of aspirin and statins.

Authors:  Matthew Spite; Charles N Serhan
Journal:  Circ Res       Date:  2010-11-12       Impact factor: 17.367

Review 6.  Treating inflammation and infection in the 21st century: new hints from decoding resolution mediators and mechanisms.

Authors:  Charles N Serhan
Journal:  FASEB J       Date:  2017-01-13       Impact factor: 5.191

7.  Anti-inflammatory effects of Chrysophyllum cainito fruit extract in lipopolysaccharide-stimulated mouse peritoneal macrophages.

Authors:  Víctor Ermilo Arana-Argáez; Gonzalo J Mena-Rejón; Julio Cesar Torres-Romero; Julio Cesar Lara-Riegos; Gumersindo López-Mirón; Rubén M Carballo
Journal:  Inflammopharmacology       Date:  2021-03-16       Impact factor: 4.473

8.  Evaluation of the chemical composition, antioxidant and anti-inflammatory activities of distillate and residue fractions of sweet basil essential oil.

Authors:  Hailong Li; Yanhui Ge; Zhimin Luo; Yulan Zhou; Xuguang Zhang; Junqing Zhang; Qiang Fu
Journal:  J Food Sci Technol       Date:  2017-04-08       Impact factor: 2.701

Review 9.  The non-haemostatic role of platelets in systemic lupus erythematosus.

Authors:  Petrus Linge; Paul R Fortin; Christian Lood; Anders A Bengtsson; Eric Boilard
Journal:  Nat Rev Rheumatol       Date:  2018-03-21       Impact factor: 20.543

10.  The Fas/Fap-1/Cav-1 complex regulates IL-1RA secretion in mesenchymal stem cells to accelerate wound healing.

Authors:  Xiaoxing Kou; Xingtian Xu; Chider Chen; Maria Laura Sanmillan; Tao Cai; Yanheng Zhou; Claudio Giraudo; Anh Le; Songtao Shi
Journal:  Sci Transl Med       Date:  2018-03-14       Impact factor: 17.956
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