Literature DB >> 20303772

Structural development studies of anti-hepatitis C virus agents with a phenanthridinone skeleton.

Masahiko Nakamura1, Atsushi Aoyama, Mohammed T A Salim, Mika Okamoto, Masanori Baba, Hiroyuki Miyachi, Yuichi Hashimoto, Hiroshi Aoyama.   

Abstract

A phenanthridinone skeleton was derived from our previous researches on thalidomide and retinoids as a multi-template for generation of anti-viral lead compounds. Structural development studies focusing on anti-hepatitis C virus activity afforded 5-butyl-2-(1,1,1,3,3,3-hexafluoro-2-hydroxypropan-2-yl)phenanthridin-6(5H)-one (10) and 5-butylbenzo[b]phenanthridin-6(5H)-one (39), which showed EC(50) values of approximately 3.7 and 3.2microM, respectively. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20303772     DOI： 10.1016/j.bmc.2010.02.057

Source DB:  PubMed          Journal:  Bioorg Med Chem        ISSN： 0968-0896            Impact factor:   3.641


  4 in total

1.  A metal-free aromative cascade for the synthesis of diverse heterocycles.

Authors:  Steven C Schlitzer; Dhanarajan Arunprasath; Katelyn G Stevens; Indrajeet Sharma
Journal:  Org Chem Front       Date:  2020-01-02       Impact factor: 5.281

2.  Palladium-catalyzed annulation of arynes by o-halobenzamides: synthesis of phenanthridinones.

Authors:  Chun Lu; Anton V Dubrovskiy; Richard C Larock
Journal:  J Org Chem       Date:  2012-09-26       Impact factor: 4.354

3.  Pd-catalyzed dehydrogenative annulation approach for the efficient synthesis of phenanthridinones.

Authors:  Xinyao Li; Jun Pan; Song Song; Ning Jiao
Journal:  Chem Sci       Date:  2016-04-26       Impact factor: 9.825

4.  Palladium-catalyzed intramolecular C-H arylation of 2-halo-N-Boc-N-arylbenzamides for the synthesis of N-H phenanthridinones.

Authors:  Quan-Fang Hu; Tian-Tao Gao; Yao-Jie Shi; Qian Lei; Luo-Ting Yu
Journal:  RSC Adv       Date:  2018-04-13       Impact factor: 4.036
  4 in total

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