Literature DB >> 20303173

A distinct expression of various gene subsets in CD34+ cells from patients with early and advanced myelodysplastic syndrome.

Alzbeta Vasikova1, Monika Belickova, Eva Budinska, Jaroslav Cermak.   

Abstract

Gene expression profiles of CD34+ cells were compared between 51 MDS patients and 7 controls. The most up-regulated genes in patients included HBG2, HBG1, CYBRD1, HSPA1B, ANGPT, and MYC, while 13 genes related to B-lymphopoiesis showed down-regulation. We observed in advanced MDS patients decreased expression of genes involved in cell cycle control, DNA repair and increased expression of proto-oncogenes, angiogenic and anti-apoptic genes. The results suggest that increased cell proliferation and resistance to apoptosis together with a loss of cell cycle control, damaged DNA repair and altered immune response may play an important role in malignant clone expansion in MDS.
Copyright © 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20303173     DOI： 10.1016/j.leukres.2010.02.021

Source DB:  PubMed          Journal:  Leuk Res        ISSN： 0145-2126            Impact factor:   3.156


  16 in total

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Journal:  Blood Adv       Date:  2021-01-26

3.  Distinctive microRNA expression profiles in CD34+ bone marrow cells from patients with myelodysplastic syndrome.

Authors:  Michaela Dostalova Merkerova; Zdenek Krejcik; Hana Votavova; Monika Belickova; Alzbeta Vasikova; Jaroslav Cermak
Journal:  Eur J Hum Genet       Date:  2010-12-08       Impact factor: 4.246

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Authors:  Sergio Matarraz; Cristina Teodosio; Carlos Fernandez; Manuel Albors; María Jara-Acevedo; Antonio López; María Gonzalez-Gonzalez; María Laura Gutierrez; Juan Flores-Montero; Carlos Cerveró; Marlies Pizarro-Perea; María Paz Garrastazul; Gonzalo Caballero; Oliver Gutierrez; Guy Daniel Mendez; Manuel González-Silva; Paula Laranjeira; Alberto Orfao
Journal:  PLoS One       Date:  2012-08-31       Impact factor: 3.240

10.  DNA repair gene variants are associated with an increased risk of myelodysplastic syndromes in a Czech population.

Authors:  Monika Belickova; Michaela Dostalova Merkerova; Eliska Stara; Jitka Vesela; Dana Sponerova; Dana Mikulenkova; Radim Brdicka; Radana Neuwirtova; Anna Jonasova; Jaroslav Cermak
Journal:  J Hematol Oncol       Date:  2013-01-22       Impact factor: 17.388
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