| Literature DB >> 20303072 |
Rémy Dureau1, Florence Robert-Gangneux, Jean-Pierre Gangneux, Caroline Nugier-Chauvin, Laurent Legentil, Richard Daniellou, Vincent Ferrières.
Abstract
The chemical synthesis of UDP-6-NHAc-6-deoxy-Galf was performed and it led to the isolation of both pure anomers. They were then evaluated together with the previously prepared UDP-furanoses for their anti-parasitic properties against Leishmania donovani promastigotes, one of the agents responsible for visceral leishmaniasis. Amongst them, the unnatural 1,2-trans UDP-6-NHAc-Galf demonstrated a high potency in inhibiting the growth of the parasite. Copyright 2010 Elsevier Ltd. All rights reserved.Entities:
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Year: 2010 PMID： 20303072 DOI： 10.1016/j.carres.2010.02.020
Source DB: PubMed Journal: Carbohydr Res ISSN： 0008-6215 Impact factor: 2.104