Literature DB >> 20302346

Zinc chloride promoted formal oxidative coupling of aromatic aldehydes and isocyanides to alpha-ketoamides.

Marinus Bouma1, Géraldine Masson, Jieping Zhu.   

Abstract

Reaction of aromatic aldehydes and isocyanides in the presence of N-methylhydroxyamine, acetic acid, and zinc chloride affords the aryl alpha-ketoamides in moderate to good yields.

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Year:  2010        PMID： 20302346     DOI： 10.1021/jo100302y

Source DB:  PubMed          Journal:  J Org Chem        ISSN： 0022-3263            Impact factor:   4.354


  3 in total

1.  Copper-catalyzed synthesis of α-ketoamides using water and dioxygen as the oxygen source.

Authors:  Yuanyuan Xiao; Zijuan Yi; Xianyong Yu; Fang Xiao
Journal:  RSC Adv       Date:  2020-08-06       Impact factor: 4.036

2.  Novel synthesis of pseudopeptides bearing a difluoromethyl group by Ugi reaction and desulfanylation.

Authors:  Jingjing Wu; Hui Li; Song Cao
Journal:  Beilstein J Org Chem       Date:  2011-08-08       Impact factor: 2.883

3.  Catalytic Enantioselective Pictet-Spengler Reaction of α-Ketoamides Catalyzed by a Single H-Bond Donor Organocatalyst.

Authors:  Rémi Andres; Qian Wang; Jieping Zhu
Journal:  Angew Chem Int Ed Engl       Date:  2022-03-11       Impact factor: 16.823
  3 in total

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