Literature DB >> 20299967

Unusual five amino acid insert within subtype C HIV-1 envelope contributes to dual-tropism (X4R5).

Elizabeth Johnston White1, Bryan McColgan, Seble Kassaye, Lynn Zijenah, David Katzenstein.   

Abstract

During the course of HIV infection, some HIV-1 viruses switch from using the CCR5 (R5) coreceptor to using CXCR4 (X4). Here, we describe two subtype C isolates from a Zimbabwean patient that switched from using R5 to using both R5 and X4 with an accompanying addition of five amino acids to the V3 loop region of envelope. The insert appears to be derived from the human genome rather than a duplication within HIV-1.

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Year:  2010        PMID： 20299967      PMCID： PMC3428204          DOI： 10.1097/QAD.0b013e328331f717

Source DB:  PubMed          Journal:  AIDS        ISSN： 0269-9370            Impact factor:   4.177


  7 in total

1.  HIV type 1 envelope subtype C sequences from recent seroconverters in Zimbabwe.

Authors:  M Batra; P C Tien; R W Shafer; C H Contag; D A Katzenstein
Journal:  AIDS Res Hum Retroviruses       Date:  2000-07-01       Impact factor: 2.205

2.  Genotypic and phenotypic analysis of a novel 15-base insertion occurring between codons 69 and 70 of HIV type 1 reverse transcriptase.

Authors:  Robert L Lobato; Eun-Young Kim; Ronald M Kagan; Thomas C Merigan
Journal:  AIDS Res Hum Retroviruses       Date:  2002-07-01       Impact factor: 2.205

3.  Longitudinal analysis of HIV type 1 subtype C envelope sequences from South Africa.

Authors:  Mia Coetzer; Tonie Cilliers; Maria Papathanasopoulos; Gita Ramjee; Salim Abdool Karim; Carolyn Williamson; Lynn Morris
Journal:  AIDS Res Hum Retroviruses       Date:  2007-02       Impact factor: 2.205

4.  Conversion rate towards a syncytium-inducing (SI) phenotype during different stages of human immunodeficiency virus type 1 infection and prognostic value of SI phenotype for survival after AIDS diagnosis.

Authors:  M Koot; R van Leeuwen; R E de Goede; I P Keet; S Danner; J K Eeftinck Schattenkerk; P Reiss; M Tersmette; J M Lange; H Schuitemaker
Journal:  J Infect Dis       Date:  1999-01       Impact factor: 5.226

5.  The CCR5 and CXCR4 coreceptors are both used by human immunodeficiency virus type 1 primary isolates from subtype C.

Authors:  Tonie Cilliers; Jabulani Nhlapo; Mia Coetzer; Dragana Orlovic; Thomas Ketas; William C Olson; John P Moore; Alexandra Trkola; Lynn Morris
Journal:  J Virol       Date:  2003-04       Impact factor: 5.103

6.  High frequency of syncytium-inducing and CXCR4-tropic viruses among human immunodeficiency virus type 1 subtype C-infected patients receiving antiretroviral treatment.

Authors:  Elizabeth R Johnston; Lynn S Zijenah; Solomon Mutetwa; Rami Kantor; Chonticha Kittinunvorakoon; David A Katzenstein
Journal:  J Virol       Date:  2003-07       Impact factor: 5.103

7.  Change in coreceptor use correlates with disease progression in HIV-1--infected individuals.

Authors:  R I Connor; K E Sheridan; D Ceradini; S Choe; N R Landau
Journal:  J Exp Med       Date:  1997-02-17       Impact factor: 14.307
  7 in total
  2 in total

1.  Extreme genetic divergence is required for coreceptor switching in HIV-1 subtype C.

Authors:  Mia Coetzer; Rebecca Nedellec; Tonie Cilliers; Tammy Meyers; Lynn Morris; Donald E Mosier
Journal:  J Acquir Immune Defic Syndr       Date:  2011-01-01       Impact factor: 3.731

2.  Coreceptor and cytokine concentrations may not explain differences in disease progression observed in HIV-1 clade A and D infected Ugandans.

Authors:  Edward Wright; Susan Mugaba; Paul Grant; Rosalind Parkes-Ratanshi; Lieve Van der Paal; Heiner Grosskurth; Pontiano Kaleebu
Journal:  PLoS One       Date:  2011-05-31       Impact factor: 3.240
  2 in total

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