OBJECTIVE: To describe a case of primary Whipple disease (WD) of the brain, which may manifest as an amnesic syndrome. MATERIALS AND METHODS: A 46-year-old woman developed primary WD of the brain. The onset was characterized by a short-term amnesic syndrome for several months before the onset of generalized tonic-clonic seizures. Her amnesia was stable throughout her illness. RESULTS: Our patient had impairment of verbal and visual memory tasks with reduced learning. Her amnesic syndrome was secondary to asymmetric bilateral hippocampal atrophy with gliosis involving the mesial temporal structures-all secondary to primary WD of the brain. CONCLUSIONS: WD may present as an amnesic syndrome and needs to be thought of as a treatable cause of cognitive dysfunction in young adults.
OBJECTIVE: To describe a case of primary Whipple disease (WD) of the brain, which may manifest as an amnesic syndrome. MATERIALS AND METHODS: A 46-year-old woman developed primary WD of the brain. The onset was characterized by a short-term amnesic syndrome for several months before the onset of generalized tonic-clonic seizures. Her amnesia was stable throughout her illness. RESULTS: Our patient had impairment of verbal and visual memory tasks with reduced learning. Her amnesic syndrome was secondary to asymmetric bilateral hippocampal atrophy with gliosis involving the mesial temporal structures-all secondary to primary WD of the brain. CONCLUSIONS:WD may present as an amnesic syndrome and needs to be thought of as a treatable cause of cognitive dysfunction in young adults.
Authors: Ioannis Zalonis; Foteini Christidi; Constantin Potagas; Michalis Rentzos; Ioannis Evdokimidis; Evangelia Kararizou Journal: Open Neurol J Date: 2015-06-26