INTRODUCTION: Upgrading of biopsy Gleason score (GS) after radical prostatectomy (RP) to GS >or=7 is common in patients with low-grade prostate cancer in biopsy. We evaluated whether a low proportion of free PSA (%fPSA) and total PSA (tPSA) predict significant upgrading after RP. PATIENTS AND METHODS: 122 patients with biopsy GS 5 or 6 prostate cancer and a tPSA <10 ng/ml who underwent RP in our academic center were included in the study. The utility of prebiopsy %fPSA and tPSA as predictors of significant upgrading was evaluated. RESULTS: Among patients undergoing RP, upgrading to GS >or=7 was found in 61 of 122 (50%) patients. A low %fPSA was a predictor of significant upgrading of tumors with biopsy GS 5 or 6 prostate cancer in patients with tPSA <10 ng/ml. CONCLUSIONS: Our results suggest that the selection of prostate cancer patients for active surveillance or re-biopsy may be improved by using %fPSA as a predictor of significant upgrading. Copyright (c) 2010 S. Karger AG, Basel.
INTRODUCTION: Upgrading of biopsy Gleason score (GS) after radical prostatectomy (RP) to GS >or=7 is common in patients with low-grade prostate cancer in biopsy. We evaluated whether a low proportion of free PSA (%fPSA) and total PSA (tPSA) predict significant upgrading after RP. PATIENTS AND METHODS: 122 patients with biopsy GS 5 or 6 prostate cancer and a tPSA <10 ng/ml who underwent RP in our academic center were included in the study. The utility of prebiopsy %fPSA and tPSA as predictors of significant upgrading was evaluated. RESULTS: Among patients undergoing RP, upgrading to GS >or=7 was found in 61 of 122 (50%) patients. A low %fPSA was a predictor of significant upgrading of tumors with biopsy GS 5 or 6 prostate cancer in patients with tPSA <10 ng/ml. CONCLUSIONS: Our results suggest that the selection of prostate cancerpatients for active surveillance or re-biopsy may be improved by using %fPSA as a predictor of significant upgrading. Copyright (c) 2010 S. Karger AG, Basel.
Authors: Vikas Mehta; Kevin Rycyna; Bart M M Baesens; Güliz A Barkan; Gladell P Paner; Robert C Flanigan; Eva M Wojcik; Girish Venkataraman Journal: Int J Clin Exp Pathol Date: 2012-07-29
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Authors: Ola Bratt; Stefan Carlsson; Erik Holmberg; Lars Holmberg; Eva Johansson; Andreas Josefsson; Annika Nilsson; Maria Nyberg; David Robinsson; Jonas Sandberg; Dag Sandblom; Pär Stattin Journal: Scand J Urol Date: 2013-07-24 Impact factor: 1.612