OBJECTIVE: There is evidence that multiple sclerosis (MS) is not only characterized by immune mediated inflammatory reactions but also by neurodegenerative processes. Neutralization of oxidative stress and excitotoxicity, might represent a therapeutic approach to provide neuroprotection in MS. The purpose of this study was to compare changes in total antioxidative status and activities of chosen antioxidative enzymes, such as: SOD, CAT in erythrocytes of patients with MS before and after using WBCT with control group. MATERIALS AND METHODS: 32 patients with multiple sclerosis (ICD10-G35) and 20 healthy subjects were recruited for the study. The examined MS group (n=16) was treated with a series of 10 daily exposures in a cryogenic chamber (2-3 min, from -120 degrees C to -110 degrees C) and program of exercises. The control MS group (n=16) had only exercises. Plasma TAS as well as SOD and CAT activities in erythrocytes were measured. RESULTS: The level of TAS in MS patients was distinctly reduced compared to healthy subjects. After two weeks of WBCT treatment an increase of TAS in the whole examined group (p>0.01) were observed in relation to control MS group. There was not increase of CuZnSOD and CAT activities. CONCLUSION: Our results suggest positive antioxidant effects of WBCT as a short-term adjuvant treatment for patients suffered due to MS.
OBJECTIVE: There is evidence that multiple sclerosis (MS) is not only characterized by immune mediated inflammatory reactions but also by neurodegenerative processes. Neutralization of oxidative stress and excitotoxicity, might represent a therapeutic approach to provide neuroprotection in MS. The purpose of this study was to compare changes in total antioxidative status and activities of chosen antioxidative enzymes, such as: SOD, CAT in erythrocytes of patients with MS before and after using WBCT with control group. MATERIALS AND METHODS: 32 patients with multiple sclerosis (ICD10-G35) and 20 healthy subjects were recruited for the study. The examined MS group (n=16) was treated with a series of 10 daily exposures in a cryogenic chamber (2-3 min, from -120 degrees C to -110 degrees C) and program of exercises. The control MS group (n=16) had only exercises. Plasma TAS as well as SOD and CAT activities in erythrocytes were measured. RESULTS: The level of TAS in MS patients was distinctly reduced compared to healthy subjects. After two weeks of WBCT treatment an increase of TAS in the whole examined group (p>0.01) were observed in relation to control MS group. There was not increase of CuZnSOD and CAT activities. CONCLUSION: Our results suggest positive antioxidant effects of WBCT as a short-term adjuvant treatment for patients suffered due to MS.
Authors: Carla Roberta Nunes Polachini; Roselia Maria Spanevello; Daniela Zanini; Jucimara Baldissarelli; Luciane Belmonte Pereira; Maria Rosa Chitolina Schetinger; Ivana Beatrice Mânica da Cruz; Charles Elias Assmann; Margarete Dulce Bagatini; Vera Maria Morsch Journal: Neurotox Res Date: 2015-12-21 Impact factor: 3.911
Authors: Anna Straburzyńska-Lupa; Magdalena Paulina Kasprzak; Mateusz Wojciech Romanowski; Anna Kwaśniewska; Wojciech Romanowski; Maria Iskra; Radosław Rutkowski Journal: Oxid Med Cell Longev Date: 2018-10-03 Impact factor: 6.543
Authors: Katarzyna Socha; Jan Kochanowicz; Elżbieta Karpińska; Jolanta Soroczyńska; Marta Jakoniuk; Zenon Mariak; Maria H Borawska Journal: Nutr J Date: 2014-06-18 Impact factor: 3.271