BACKGROUND AND PURPOSE: Imaging studies have shown that children with NF-1 have increased brain volumes compared with age-matched controls and the CCs are disproportionately large. The purpose of this study was to determine if the CC in adults with NF-1 differed from that in matched controls by using DTI and volumetric imaging. MATERIALS AND METHODS: MR imaging with DTI was performed in 10 adults with NF-1 and in 10 age-, sex-, and handedness-matched controls by using a 3T system. Total brain volumes and the areas and central lengths of the CC were calculated, along with the radial width of callosal subdivisions, in the 2 groups. RESULTS: Our results showed that the total brain volume was not significantly different between adults with NF-1 and matched controls. The length and total cross-sectional area of the CC were statistically larger in adults with NF-1 compared with controls (approximately 10% longer and 20% greater area). On DTI we found a preservation of the primary eigenvalue with increases in the minor eigenvalues at the genu. CONCLUSIONS: We have shown that the increased size of the CC found in children with NF-1 is also present in adults with the syndrome, whereas no difference in total brain volume was found.
BACKGROUND AND PURPOSE: Imaging studies have shown that children with NF-1 have increased brain volumes compared with age-matched controls and the CCs are disproportionately large. The purpose of this study was to determine if the CC in adults with NF-1 differed from that in matched controls by using DTI and volumetric imaging. MATERIALS AND METHODS: MR imaging with DTI was performed in 10 adults with NF-1 and in 10 age-, sex-, and handedness-matched controls by using a 3T system. Total brain volumes and the areas and central lengths of the CC were calculated, along with the radial width of callosal subdivisions, in the 2 groups. RESULTS: Our results showed that the total brain volume was not significantly different between adults with NF-1 and matched controls. The length and total cross-sectional area of the CC were statistically larger in adults with NF-1 compared with controls (approximately 10% longer and 20% greater area). On DTI we found a preservation of the primary eigenvalue with increases in the minor eigenvalues at the genu. CONCLUSIONS: We have shown that the increased size of the CC found in children with NF-1 is also present in adults with the syndrome, whereas no difference in total brain volume was found.
Authors: Marieke Klein; Marjolein van Donkelaar; Ellen Verhoef; Barbara Franke Journal: Am J Med Genet B Neuropsychiatr Genet Date: 2017-07 Impact factor: 3.568
Authors: João V Duarte; Maria J Ribeiro; Inês R Violante; Gil Cunha; Eduardo Silva; Miguel Castelo-Branco Journal: Hum Brain Mapp Date: 2012-09-11 Impact factor: 5.038
Authors: Steffie N Tomson; Matthew J Schreiner; Manjari Narayan; Tena Rosser; Nicole Enrique; Alcino J Silva; Genevera I Allen; Susan Y Bookheimer; Carrie E Bearden Journal: Hum Brain Mapp Date: 2015-08-25 Impact factor: 5.038
Authors: Katherine H Karlsgodt; Tena Rosser; Evan S Lutkenhoff; Tyrone D Cannon; Alcino Silva; Carrie E Bearden Journal: PLoS One Date: 2012-10-19 Impact factor: 3.240