Literature DB >> 20299009

IFNgamma primes macrophages for inflammatory activation by high molecular weight hyaluronan.

Mark A Wallet1, Shannon M Wallet, Giorgio Guiulfo, John W Sleasman, Maureen M Goodenow.   

Abstract

The objective was to assess outcomes of IFNgamma-priming upon macrophage activation by the synovial macromolecule high molecular weight hyaluronan [HMW-HA] in the context of rheumatoid arthritis inflammation. Human macrophages primed by IFNgamma and activated by HMW-HA were evaluated for cytokine secretion by ELISA and Milliplex assay and activation profiles by nuclear transcription factor EIA. IFNgamma-primed, HMW-HA-activated macrophages produced elevated levels of TNF and secreted the TH1 cytokine IL-12p70, while IFNgamma suppressed HMW-HA-induced secretion of the regulatory cytokine IL-10 and activation of the transcription factor c-Jun. IFNgamma modulates the HMW-HA-induced cytokine response profile promoting macrophage activation and inflammatory TH1 cytokine secretion. Copyright 2010 Elsevier Inc. All rights reserved.

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Year:  2010        PMID： 20299009      PMCID： PMC2891046          DOI： 10.1016/j.cellimm.2010.02.013

Source DB:  PubMed          Journal:  Cell Immunol        ISSN： 0008-8749            Impact factor:   4.868


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