Literature DB >> 20298749

Intra-amygdala injections of neuropeptide S block fear-potentiated startle.

Markus Fendt1, Stefan Imobersteg2, Hugo Bürki2, Kevin H McAllister2, Andreas W Sailer3.   

Abstract

Injections of neuropeptide S (NPS) into the lateral ventricle induce a strong hyperactivity. Since most behavioral paradigms are dependent of spontaneous locomotor activity, this makes it difficult to interpret the role of NPS in such paradigms. The aim of the present experiment was to investigate the effects of NPS in fear-potentiated startle, a behavioral fear paradigm which we believe is less sensitive to general changes in locomotor activity. Furthermore, NPS was directly injected into the amygdala, the central site of the neural fear circuitry. Our data shows that intra-amygdala NPS injections dose-dependently block the expression of conditioned fear and that this effect is independent of NPS effects on locomotor activity. This strongly supports a crucial role of amygdaloid NPS in conditioned fear. 2010 Elsevier Ireland Ltd. All rights reserved.

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Year:  2010        PMID： 20298749     DOI： 10.1016/j.neulet.2010.03.028

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  21 in total

1.  Neuropeptide S stimulates dopaminergic neurotransmission in the medial prefrontal cortex.

Authors:  Wei Si; Leah Aluisio; Naoe Okamura; Stewart D Clark; Ian Fraser; Steven W Sutton; Pascal Bonaventure; Rainer K Reinscheid
Journal:  J Neurochem       Date:  2010-08-30       Impact factor: 5.372

2.  Intranasally administered neuropeptide S (NPS) exerts anxiolytic effects following internalization into NPS receptor-expressing neurons.

Authors:  Irina A Ionescu; Julien Dine; Yi-Chun Yen; Dominik R Buell; Leonie Herrmann; Florian Holsboer; Matthias Eder; Rainer Landgraf; Ulrike Schmidt
Journal:  Neuropsychopharmacology       Date:  2012-01-25       Impact factor: 7.853

3.  Activation of neuropeptide S-expressing neurons in the locus coeruleus by corticotropin-releasing factor.

Authors:  Kay Jüngling; Xiaobin Liu; Jörg Lesting; Philippe Coulon; L Sosulina; Rainer K Reinscheid; Hans-Christian Pape
Journal:  J Physiol       Date:  2012-05-08       Impact factor: 5.182

4.  Modification of caffeine effects on the affect-modulated startle by neuropeptide S receptor gene variation.

Authors:  Katharina Domschke; Benedikt Klauke; Bernward Winter; Agnes Gajewska; Martin J Herrmann; Bodo Warrings; Andreas Mühlberger; Katherina Wosnitza; Andrea Dlugos; Swantje Naunin; Kathrin Nienhaus; Manfred Fobker; Christian Jacob; Volker Arolt; Paul Pauli; Andreas Reif; Peter Zwanzger; Jürgen Deckert
Journal:  Psychopharmacology (Berl)       Date:  2012-03-08       Impact factor: 4.530

5.  Prevention of stress-impaired fear extinction through neuropeptide s action in the lateral amygdala.

Authors:  Frédéric Chauveau; Maren Denise Lange; Kay Jüngling; Jörg Lesting; Thomas Seidenbecher; Hans-Christian Pape
Journal:  Neuropsychopharmacology       Date:  2012-02-01       Impact factor: 7.853

6.  Neuropeptide S: a novel regulator of pain-related amygdala plasticity and behaviors.

Authors:  Wenjie Ren; Takaki Kiritoshi; Stéphanie Grégoire; Guangchen Ji; Remo Guerrini; Girolamo Calo; Volker Neugebauer
Journal:  J Neurophysiol       Date:  2013-07-24       Impact factor: 2.714

7.  Oxytocin reduces background anxiety in a fear-potentiated startle paradigm.

Authors:  Galen Missig; Luke W Ayers; Jay Schulkin; Jeffrey B Rosen
Journal:  Neuropsychopharmacology       Date:  2010-09-15       Impact factor: 7.853

8.  The impact of early neglect on defensive and appetitive physiology during the pubertal transition: a study of startle and postauricular reflexes.

Authors:  Karina Quevedo; Anna E Johnson; Michelle M Loman; Theresa Lafavor; Bao Moua; Megan R Gunnar
Journal:  Dev Psychobiol       Date:  2015-03-13       Impact factor: 3.038

9.  Neuroleptics Affect Neuropeptide S and NPSR mRNA Levels in the Rat Brain.

Authors:  Artur Pałasz; Ewa Rojczyk
Journal:  J Mol Neurosci       Date:  2015-07-31       Impact factor: 3.444

Review 10.  Amygdala, neuropeptides, and chronic pain-related affective behaviors.

Authors:  Volker Neugebauer; Mariacristina Mazzitelli; Bryce Cragg; Guangchen Ji; Edita Navratilova; Frank Porreca
Journal:  Neuropharmacology       Date:  2020-03-15       Impact factor: 5.250
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