BACKGROUND: Little is known about the relation between regular use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of asthma at the population level. The aim of this study was to examine a possible association between intake of NSAIDs and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary postal questionnaire surveys concerning health and lifestyle, we prospectively studied 19 349 adult twins enrolled in the nationwide Danish Twin Registry. RESULTS: We found a higher prevalence of new-onset asthma in subjects who used NSAIDs (other than aspirin) regularly compared with non-users (7.7% vs 4.3%), OR = 1.87 (1.25-2.81), P = 0.002. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema and intake of medications other than NSAIDs, OR = 1.90 (1.26-2.85), P = 0.002. CONCLUSIONS: Regular use of NSAIDs other than aspirin may be a risk factor for adult-onset asthma. This observation must be accommodated in explanations of the relationship between use of analgesics and risk of asthma.
BACKGROUND: Little is known about the relation between regular use of non-steroidal anti-inflammatory drugs (NSAIDs) and the risk of asthma at the population level. The aim of this study was to examine a possible association between intake of NSAIDs and risk of adult-onset asthma. METHODS: Using data from two multidisciplinary postal questionnaire surveys concerning health and lifestyle, we prospectively studied 19 349 adult twins enrolled in the nationwide Danish Twin Registry. RESULTS: We found a higher prevalence of new-onset asthma in subjects who used NSAIDs (other than aspirin) regularly compared with non-users (7.7% vs 4.3%), OR = 1.87 (1.25-2.81), P = 0.002. The result remained significant after adjusting for sex, age, smoking, BMI, hay fever, eczema and intake of medications other than NSAIDs, OR = 1.90 (1.26-2.85), P = 0.002. CONCLUSIONS: Regular use of NSAIDs other than aspirin may be a risk factor for adult-onset asthma. This observation must be accommodated in explanations of the relationship between use of analgesics and risk of asthma.
Authors: Weisong Zhou; Shinji Toki; Jian Zhang; Kasia Goleniewksa; Dawn C Newcomb; Jacqueline Y Cephus; Daniel E Dulek; Melissa H Bloodworth; Matthew T Stier; Vasiliy Polosuhkin; Rama D Gangula; Simon A Mallal; David H Broide; R Stokes Peebles Journal: Am J Respir Crit Care Med Date: 2016-01-01 Impact factor: 21.405
Authors: Weisong Zhou; Kasia Goleniewska; Jian Zhang; Daniel E Dulek; Shinji Toki; Matthew T Lotz; Dawn C Newcomb; Madison G Boswell; Vasiliy V Polosukhin; Ginger L Milne; Pingsheng Wu; Martin L Moore; Garret A FitzGerald; R Stokes Peebles Journal: J Allergy Clin Immunol Date: 2014-07-18 Impact factor: 10.793
Authors: Zbigniew Zasłona; Katsuhide Okunishi; Emilie Bourdonnay; Racquel Domingo-Gonzalez; Bethany B Moore; Nicholas W Lukacs; David M Aronoff; Marc Peters-Golden Journal: J Allergy Clin Immunol Date: 2013-09-24 Impact factor: 10.793