Literature DB >> 20297778

Phospholipid complexation of general anesthetics in fluid bilayers.

Serhan Turkyilmaz1, Hideyuki Mitomo, Wen-Hua Chen, Steven L Regen.   

Abstract

A nearest-neighbor recognition analysis has been performed in cholesterol-rich and cholesterol-poor liposomes derived from 1,2-dipalmitoyl-sn-glycero-3-phosphocholine (DPPC) in the presence of varying concentrations of chloroform. This analysis has yielded a fundamentally new, molecular-level view of the interaction of general anesthetics with lipid bilayers, which may be relevant to their biological action; that is, DPPC forms 1:1 complexes with CHCl(3) in both membranes in the fluid bilayer state.

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Year:  2010        PMID： 20297778      PMCID： PMC2856843          DOI： 10.1021/la100712y

Source DB:  PubMed          Journal:  Langmuir        ISSN： 0743-7463            Impact factor:   3.882


  16 in total

1.  The structural role of cholesterol in biological membranes.

Authors:  M Sugahara; M Uragami; X Yan; S L Regen
Journal:  J Am Chem Soc       Date:  2001-08-15       Impact factor: 15.419

2.  A chemical sensor for the liquid-ordered phase.

Authors:  Honghua Cao; Jianbing Zhang; Bingwen Jing; Steven L Regen
Journal:  J Am Chem Soc       Date:  2005-06-22       Impact factor: 15.419

Review 3.  Molecular targets underlying general anaesthesia.

Authors:  Nicholas P Franks
Journal:  Br J Pharmacol       Date:  2006-01       Impact factor: 8.739

Review 4.  Selective actions of volatile general anaesthetics at molecular and cellular levels.

Authors:  N P Franks; W R Lieb
Journal:  Br J Anaesth       Date:  1993-07       Impact factor: 9.166

Review 5.  The lateral pressure profile in membranes: a physical mechanism of general anesthesia.

Authors:  R S Cantor
Journal:  Biochemistry       Date:  1997-03-04       Impact factor: 3.162

6.  Saturable and unsaturable binding of a volatile anesthetic enflurane with model lipid vesicle membranes.

Authors:  T Yoshida; H Okabayashi; H Kamaya; I Ueda
Journal:  Biochim Biophys Acta       Date:  1989-03-13

Review 7.  Lipid raft microdomains and neurotransmitter signalling.

Authors:  John A Allen; Robyn A Halverson-Tamboli; Mark M Rasenick
Journal:  Nat Rev Neurosci       Date:  2006-12-29       Impact factor: 34.870

8.  Anesthetic potency of two novel synthetic polyhydric alkanols longer than the n-alkanol cutoff: evidence for a bilayer-mediated mechanism of anesthesia?

Authors:  Justin T Mohr; Gordon W Gribble; Susan S Lin; Roderic G Eckenhoff; Robert S Cantor
Journal:  J Med Chem       Date:  2005-06-16       Impact factor: 7.446

9.  Cholesterol-induced fluid-phase immiscibility in membranes.

Authors:  M B Sankaram; T E Thompson
Journal:  Proc Natl Acad Sci U S A       Date:  1991-10-01       Impact factor: 11.205

Review 10.  Thermodynamics of lipid interactions in complex bilayers.

Authors:  Paulo F F Almeida
Journal:  Biochim Biophys Acta       Date:  2008-08-15
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  2 in total

1.  Effects of isoflurane, halothane, and chloroform on the interactions and lateral organization of lipids in the liquid-ordered phase.

Authors:  Serhan Turkyilmaz; Paulo F Almeida; Steven L Regen
Journal:  Langmuir       Date:  2011-10-28       Impact factor: 3.882

2.  Atomistic study of lipid membranes containing chloroform: looking for a lipid-mediated mechanism of anesthesia.

Authors:  Ramon Reigada
Journal:  PLoS One       Date:  2013-01-02       Impact factor: 3.240
  2 in total

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