| Literature DB >> 2029620 |
J C Louis1, E Magal, A Brixi, R Steinberg, E Yavin, G Vincendon.
Abstract
Acute forebrain ischemia reduced protein kinase C (PKC) activity in the adult rat cortex, striatum and hippocampus by 60-70% after 20 min ischemia episodes, followed by 48 h of recirculation. Ischemia of 1 min, followed by recirculation, produced a less pronounced but significant decrease in PKC activity. The ischemia-induced decrease of PKC affected both the soluble and the membrane-bound kinase. Alterations of PKC predate neuronal death following ischemia.Entities:
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Year: 1991 PMID： 2029620 DOI： 10.1016/0006-8993(91)91094-h
Source DB: PubMed Journal: Brain Res ISSN： 0006-8993 Impact factor: 3.252