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Literature DB >> 202950

5'-Terminal sequences and coding region of late simian virus 40 mRNAs are derived from noncontiguous segments of the viral genome.

Abstract

The region of the simian virus 40 genome complementary to the 5' end of the most abundant poly(A)-containing 19S and 16S mRNAs was mapped by hybridization of double-labeled RNA ([3H]methyl group and [14C]uridine) to specific DNA fragments. Chemical identification of methylated residues indicated that a common "leader" sequence adjacent to the 5' terminus of both 19S and 16S mRNA is transcribed from DNA sequences located between 0.67 and 0.76 map units. The estimated size of this "leader" RNA, which does not code for any known viral protein, is 170-200 nucleotides. Our results indicate that sequences complementary to the "leader" region and coding portion of 16S mRNA are located in separate parts of the simian virus 40 genome.

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Year: 1977 PMID： 202950 PMCID： PMC431702 DOI： 10.1073/pnas.74.12.5323

Source DB: PubMed Journal: Proc Natl Acad Sci U S A ISSN： 0027-8424 Impact factor: 11.205

15 in total

1. Capping of eucaryotic mRNAs.

Authors: A J Shatkin
Journal: Cell Date: 1976-12 Impact factor: 41.582

2. Translational discrimination of 'capped' and 'non-capped' mRNAS: inhibition of a series of chemical analogs of m7GpppX.

Authors: D Canaani; M Revel; Y Groner
Journal: FEBS Lett Date: 1976-05-01 Impact factor: 4.124

3. The arrangement of simian virus 40 sequences in the DNA of transformed cells.

Authors: M Botchan; W Topp; J Sambrook
Journal: Cell Date: 1976-10 Impact factor: 41.582

4. An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

Authors: L T Chow; R E Gelinas; T R Broker; R J Roberts
Journal: Cell Date: 1977-09 Impact factor: 41.582

5. Two adenovirus mRNAs have a common 5' terminal leader sequence encoded at least 10 kb upstream from their main coding regions.

Authors: D F Klessig
Journal: Cell Date: 1977-09 Impact factor: 41.582

6. Isolation and characterization of simian virus 40 ribonucleic acid.

Authors: R A Weinberg; S O Warnaar; E Winocour
Journal: J Virol Date: 1972-08 Impact factor: 5.103

7. Mapping of transcription sites of simian virus 40-specific late 16S and 19S mRNA by electron microscopy.

Authors: E May; J V Maizel; N P Salzman
Journal: Proc Natl Acad Sci U S A Date: 1977-02 Impact factor: 11.205

8. Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.

Authors: Y Aloni; R Dhar; O Laub; M Horowitz; G Khoury
Journal: Proc Natl Acad Sci U S A Date: 1977-09 Impact factor: 11.205

9. Mapping of sequences with 2-fold symmetry on the simian virus 40 genome: a photochemical crosslinking approach.

Authors: C K Shen; J E Hearst
Journal: Proc Natl Acad Sci U S A Date: 1977-04 Impact factor: 11.205

10. Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

Authors: S M Berget; C Moore; P A Sharp
Journal: Proc Natl Acad Sci U S A Date: 1977-08 Impact factor: 11.205

25 in total

1. Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA.

Authors: D Canaani; C Kahana; S Lavi; Y Groner
Journal: Nucleic Acids Res Date: 1979-06-25 Impact factor: 16.971

2. Segments of simian virus 40 DNA spanning most of the leader sequence of the major late viral messenger RNA are dispensable.

Authors: K N Subramanian
Journal: Proc Natl Acad Sci U S A Date: 1979-06 Impact factor: 11.205

3. Transcription pattern of in vivo-labeled late simian virus 40 RNA: equimolar transcription beyond the mRNA 3' terminus.

Authors: J P Ford; M T Hsu
Journal: J Virol Date: 1978-12 Impact factor: 5.103

5'-Terminal sequences and coding region of late simian virus 40 mRNAs are derived from noncontiguous segments of the viral genome.

1. Capping of eucaryotic mRNAs.

2. Translational discrimination of 'capped' and 'non-capped' mRNAS: inhibition of a series of chemical analogs of m7GpppX.

3. The arrangement of simian virus 40 sequences in the DNA of transformed cells.

4. An amazing sequence arrangement at the 5' ends of adenovirus 2 messenger RNA.

5. Two adenovirus mRNAs have a common 5' terminal leader sequence encoded at least 10 kb upstream from their main coding regions.

6. Isolation and characterization of simian virus 40 ribonucleic acid.

7. Mapping of transcription sites of simian virus 40-specific late 16S and 19S mRNA by electron microscopy.

8. Novel mechanism for RNA maturation: the leader sequences of simian virus 40 mRNA are not transcribed adjacent to the coding sequences.

9. Mapping of sequences with 2-fold symmetry on the simian virus 40 genome: a photochemical crosslinking approach.

10. Spliced segments at the 5' terminus of adenovirus 2 late mRNA.

1. Identification and mapping of N6-methyladenosine containing sequences in simian virus 40 RNA.

2. Segments of simian virus 40 DNA spanning most of the leader sequence of the major late viral messenger RNA are dispensable.

3. Transcription pattern of in vivo-labeled late simian virus 40 RNA: equimolar transcription beyond the mRNA 3' terminus.

4. Mutational alterations within the simian virus 40 leader segment generate altered 16S and 19S mRNA's.

5. Deletion mutants of simian virus 40 defective in biosynthesis of late viral mRNA.

6. Polyoma virus giant RNAs contain tandem repeats of the nucleotide sequence of the entire viral genome.

7. Electron microscopic mapping of RNA transcribed from the late region of polyoma virus DNA.

8. Characterization of the major altered leader sequence of late mRNA induced by SV40 deletion mutant d1-1811.

9. Localization of the 5' terminus of late SV40 mRNA.

10. Transcription of a defective polyoma virus genome.