Literature DB >> 2027763

The DNA binding properties of the MutL protein isolated from Escherichia coli.

S M Bende1, R H Grafström.   

Abstract

The mutL gene of Escherichia coli, which is involved in the repair of mispaired and unpaired nucleotides in DNA, has been independently cloned and the gene product purified. In addition to restoring methyl-directed DNA repair in extracts prepared from mutL strains, the purified MutL protein binds to both double and single stranded DNA. The affinity constant of MutL for unmethylated single stranded DNA was twice that of its affinity constant for methylated single stranded DNA and methylated or unmethylated double stranded DNA. The binding of MutL to double stranded DNA was not affected by the pattern of DNA methylation or the presence of a MutHLS-repairable lesion.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 2027763      PMCID： PMC333914          DOI： 10.1093/nar/19.7.1549

Source DB:  PubMed          Journal:  Nucleic Acids Res        ISSN： 0305-1048            Impact factor:   16.971


  26 in total

1.  Methyl-directed repair of frameshift heteroduplexes in cell extracts from Escherichia coli.

Authors:  B A Learn; R H Grafstrom
Journal:  J Bacteriol       Date:  1989-12       Impact factor: 3.490

Review 2.  Mechanisms of DNA-mismatch correction.

Authors:  M Grilley; J Holmes; B Yashar; P Modrich
Journal:  Mutat Res       Date:  1990 Sep-Nov       Impact factor: 2.433

3.  Escherichia coli mutS-encoded protein binds to mismatched DNA base pairs.

Authors:  S S Su; P Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  1986-07       Impact factor: 11.205

4.  Deletions of bases in one strand of duplex DNA, in contrast to single-base mismatches, produce highly kinked molecules: possible relevance to the folding of single-stranded nucleic acids.

Authors:  C H Hsieh; J D Griffith
Journal:  Proc Natl Acad Sci U S A       Date:  1989-07       Impact factor: 11.205

Review 5.  DNA mismatch correction.

Authors:  P Modrich
Journal:  Annu Rev Biochem       Date:  1987       Impact factor: 23.643

6.  Different base/base mismatches are corrected with different efficiencies by the methyl-directed DNA mismatch-repair system of E. coli.

Authors:  B Kramer; W Kramer; H J Fritz
Journal:  Cell       Date:  1984-10       Impact factor: 41.582

7.  Cloning of mutH and identification of the gene product.

Authors:  R H Grafstrom; R H Hoess
Journal:  Gene       Date:  1983 May-Jun       Impact factor: 3.688

8.  Repair of defined single base-pair mismatches in Escherichia coli.

Authors:  C Dohet; R Wagner; M Radman
Journal:  Proc Natl Acad Sci U S A       Date:  1985-01       Impact factor: 11.205

9.  Identification and characterization of the mutL and mutS gene products of Salmonella typhimurium LT2.

Authors:  P P Pang; A S Lundberg; G C Walker
Journal:  J Bacteriol       Date:  1985-09       Impact factor: 3.490

10.  GATC sequences, DNA nicks and the MutH function in Escherichia coli mismatch repair.

Authors:  F Längle-Rouault; G Maenhaut-Michel; M Radman
Journal:  EMBO J       Date:  1987-04       Impact factor: 11.598
View more
  25 in total

1.  hMutSalpha forms an ATP-dependent complex with hMutLalpha and hMutLbeta on DNA.

Authors:  Guido Plotz; Jochen Raedle; Angela Brieger; Jörg Trojan; Stefan Zeuzem
Journal:  Nucleic Acids Res       Date:  2002-02-01       Impact factor: 16.971

2.  Spontaneously arising mutL mutators in evolving Escherichia coli populations are the result of changes in repeat length.

Authors:  Aaron C Shaver; Paul D Sniegowski
Journal:  J Bacteriol       Date:  2003-10       Impact factor: 3.490

3.  Structure of the MutL C-terminal domain: a model of intact MutL and its roles in mismatch repair.

Authors:  Alba Guarné; Santiago Ramon-Maiques; Erika M Wolff; Rodolfo Ghirlando; Xiaojian Hu; Jeffrey H Miller; Wei Yang
Journal:  EMBO J       Date:  2004-10-07       Impact factor: 11.598

4.  The Escherichia coli MutL protein stimulates binding of Vsr and MutS to heteroduplex DNA.

Authors:  K Drotschmann; A Aronshtam; H J Fritz; M G Marinus
Journal:  Nucleic Acids Res       Date:  1998-02-15       Impact factor: 16.971

5.  DNA binding by yeast Mlh1 and Pms1: implications for DNA mismatch repair.

Authors:  Mark C Hall; Polina V Shcherbakova; John M Fortune; Christoph H Borchers; J Michael Dial; Kenneth B Tomer; Thomas A Kunkel
Journal:  Nucleic Acids Res       Date:  2003-04-15       Impact factor: 16.971

6.  Evidence for a physical interaction between the Escherichia coli methyl-directed mismatch repair proteins MutL and UvrD.

Authors:  M C Hall; J R Jordan; S W Matson
Journal:  EMBO J       Date:  1998-03-02       Impact factor: 11.598

7.  PMS1 from Arabidopsis thaliana: optimization of protein overexpression in Escherichia coli.

Authors:  Celina Galles; Rodrigo L Gomez; Claudia P Spampinato
Journal:  Mol Biol Rep       Date:  2010-06-23       Impact factor: 2.316

Review 8.  DNA mismatch repair and Lynch syndrome.

Authors:  Guido Plotz; Stefan Zeuzem; Jochen Raedle
Journal:  J Mol Histol       Date:  2006-07-04       Impact factor: 2.611

9.  Restoration of mismatch repair to nuclear extracts of H6 colorectal tumor cells by a heterodimer of human MutL homologs.

Authors:  G M Li; P Modrich
Journal:  Proc Natl Acad Sci U S A       Date:  1995-03-14       Impact factor: 11.205

Review 10.  Functions of the gene products of Escherichia coli.

Authors:  M Riley
Journal:  Microbiol Rev       Date:  1993-12
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.