Literature DB >> 2027498

Von Hippel-Lindau disease and erythrocytosis: radioimmunoassay of erythropoietin in cyst fluid from a brainstem hemangioblastoma.

J C Horton1, G R Harsh, J W Fisher, W F Hoyt.   

Abstract

A 59-year-old woman with von Hippel-Lindau disease developed erythrocytosis and a recurrent intracranial hemangioblastoma. Radioimmunoassay showed an elevated level of erythropoietin in her serum. Cyst fluid from the tumor also contained erythropoietin, concentrated a thousandfold relative to the serum level. Production of erythropoietin by hemangioblastomas may explain the erythrocytosis present in some patients with von Hippel-Lindau disease.

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Year:  1991        PMID: 2027498     DOI: 10.1212/wnl.41.5.753

Source DB:  PubMed          Journal:  Neurology        ISSN: 0028-3878            Impact factor:   9.910


  5 in total

1.  Cerebellar hemangioblastoma presenting as secondary erythrocytosis and aspiration pneumonia.

Authors:  H M Farrukh
Journal:  West J Med       Date:  1996-02

2.  Cerebellar hemangioblastoma in a patient with von hippel-lindau disease : a case report.

Authors:  D Abd Hamid; J Abdullah; A Ariff; M Muhamad; M Madhavan
Journal:  Malays J Med Sci       Date:  2000-07

3.  Loss of Quiescence in von Hippel-Lindau Hemangioblastomas is Associated with Erythropoietin Signaling.

Authors:  Michael J Feldman; Saman Sizdahkhani; Nancy A Edwards; Marsha J Merrill; Abhik Ray-Chaudhury; Zhengping Zhuang; Russell R Lonser; Edward H Oldfield; Prashant Chittiboina
Journal:  Sci Rep       Date:  2016-10-17       Impact factor: 4.379

Review 4.  The role of PHD2 mutations in the pathogenesis of erythrocytosis.

Authors:  Betty Gardie; Melanie J Percy; David Hoogewijs; Rasheduzzaman Chowdhury; Celeste Bento; Patrick R Arsenault; Stéphane Richard; Helena Almeida; Joanne Ewing; Frédéric Lambert; Mary Frances McMullin; Christopher J Schofield; Frank S Lee
Journal:  Hypoxia (Auckl)       Date:  2014-07-01

5.  Polyglobulia in patients with hemangioblastomas is related to tumor size but not to serum erythropoietin.

Authors:  Marie T Krüger; Jan-Helge Klingler; Cordula Jilg; Christine Steiert; Stefan Zschiedrich; Vera Van Velthoven; Sven Gläsker
Journal:  Hered Cancer Clin Pract       Date:  2018-09-11       Impact factor: 2.857

  5 in total

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