| Literature DB >> 2026474 |
M Okamoto1, M Sasano, M Goto, K Nishioka, S Aotsuka, K Nakamura, R Yokohari.
Abstract
We developed an ELISA system for human IL-1 alpha and -beta release from silica-stimulated monocytes from healthy volunteers and tested the effect of several anti-rheumatic drugs including nonsteroidal anti-inflammatory drug (Ibuprofen). Anti-rheumatic drugs including Auranofin and Sulphasalazine suppressed IL-1 beta release significantly at therapeutic concentrations, whereas Bucillamine, Lobenzarit, D-Penicillamine and Ibuprofen did not. These results suggest a possible immunotherapeutic effectiveness of some anti-rheumatic drugs on rheumatoid arthritis through their inhibition of IL-1 beta release.Entities:
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Year: 1991 PMID： 2026474 DOI： 10.1016/0192-0561(91)90023-z
Source DB: PubMed Journal: Int J Immunopharmacol ISSN： 0192-0561