Literature DB >> 2026452

Stimulation of Ig production and growth of human lymphoblastoid B-cell lines by nerve growth factor.

H Kimata1, A Yoshida, C Ishioka, H Mikawa.   

Abstract

The effects of nerve growth factor (NGF) on human lymphoblastoid B-cell lines were studied. NGF increased Ig production and proliferation by lymphoblastoid B-cell lines GM-1500, GM-1056 and CBL in a dose-dependent manner. As little as 0.01 ng/ml of NGF was effective. This effect was blocked by anti-NGF serum but not by control serum. Other cytokines, including interleukin (IL)-1 beta, IL-2, IL-4, IL-5, interferon (IFN)-alpha, IFN-beta, IFN-gamma and granulocyte-macrophage colony-stimulating factor (GM-CSF), did not stimulate Ig production. These results indicate that, in addition to its neurotropic effect NGF also acts as B-cell stimulatory factor.

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Year:  1991        PMID： 2026452      PMCID： PMC1384411     

Source DB:  PubMed          Journal:  Immunology        ISSN： 0019-2805            Impact factor:   7.397


  8 in total

1.  Nerve growth factor induces growth and differentiation of human B lymphocytes.

Authors:  U Otten; P Ehrhard; R Peck
Journal:  Proc Natl Acad Sci U S A       Date:  1989-12       Impact factor: 11.205

2.  Subset of natural killer cells is induced by immune complexes to display Fc receptors for IgE and IgA and demonstrates isotype regulatory function.

Authors:  H Kimata; A Saxon
Journal:  J Clin Invest       Date:  1988-07       Impact factor: 14.808

Review 3.  Multiple sclerosis: the blood-brain-barrier and the measurement of de novo central nervous system IgG synthesis.

Authors:  W W Tourtellotte; B I Ma
Journal:  Neurology       Date:  1978-09       Impact factor: 9.910

4.  On the cellular source and function of interleukin 6 produced in the central nervous system in viral diseases.

Authors:  K Frei; U V Malipiero; T P Leist; R M Zinkernagel; M E Schwab; A Fontana
Journal:  Eur J Immunol       Date:  1989-04       Impact factor: 5.532

5.  Human natural killer (NK) cells produce a late-acting B-cell differentiation activity.

Authors:  H Kimata; E H Sherr; A Saxon
Journal:  J Clin Immunol       Date:  1988-09       Impact factor: 8.317

6.  Protection from guanethidine-induced neuronal destruction by nerve growth factor: effect of NGF on immune function.

Authors:  P T Manning; J H Russell; B Simmons; E M Johnson
Journal:  Brain Res       Date:  1985-08-05       Impact factor: 3.252

7.  Nerve growth factor promotes human hemopoietic colony growth and differentiation.

Authors:  H Matsuda; M D Coughlin; J Bienenstock; J A Denburg
Journal:  Proc Natl Acad Sci U S A       Date:  1988-09       Impact factor: 11.205

8.  Constitutive production of B cell differentiation factor-like activity by human T and B cell lines.

Authors:  S Kanowith-Klein; A Saxon; C H Uittenbogaart
Journal:  Eur J Immunol       Date:  1987-05       Impact factor: 5.532
  8 in total
  4 in total

Review 1.  Neurotrophins and the immune system.

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Journal:  J Anat       Date:  2003-07       Impact factor: 2.610

2.  Vasoactive intestinal peptide stimulates immunoglobulin production and growth of human B cells.

Authors:  C Ishioka; A Yoshida; H Kimata; H Mikawa
Journal:  Clin Exp Immunol       Date:  1992-03       Impact factor: 4.330

3.  Determination of serum interleukin-13 and nerve growth factor in patients with systemic lupus erythematosus and clinical significance.

Authors:  Zusen Xu; Yanlei Chen
Journal:  J Huazhong Univ Sci Technolog Med Sci       Date:  2005

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Authors:  K Titanji; A Nilsson; C Mörch; A Samuelsson; A Sönnerborg; S Grutzmeier; M Zazzi; A De Milito
Journal:  Clin Exp Immunol       Date:  2003-05       Impact factor: 4.330
  4 in total

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