| Literature DB >> 2026249 |
M L Standaert1, J Sasse, D R Cooper, R V Farese.
Abstract
Treatment of intact adipocytes with the autoregulatory PKC pseudosubstrate PKC(19-31) inhibited insulin-stimulated hexose uptake and lipogenesis, with no effect on basal values. The effect was dose-dependent with respective IC50 values of 30 microM and 600 microM for insulin-stimulated hexose uptake in electroporated and intact adipocytes. These studies indicate that PKC may play a role in the mediation of insulin action in adipocytes.Entities:
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Year: 1991 PMID： 2026249 DOI： 10.1016/0014-5793(91)80463-d
Source DB: PubMed Journal: FEBS Lett ISSN： 0014-5793 Impact factor: 4.124