Literature DB >> 2025730

Cholesterol screening and life assurance.

H A Neil1, D Mant.   

Abstract

OBJECTIVES: To examine how insurance companies assess proposals for life assurance from applicants with raised cholesterol concentrations and to determine the excess mortality rating applied.
DESIGN: Survey of 49 companies underwriting term life assurance.
SETTING: United Kingdom.
SUBJECTS: Four fictional men aged 30 seeking 20 year term policies paying benefit only on death. Two had total cholesterol concentrations of 6.4 and 8.1 mmol/l but no other cardiovascular risk factors; one was overweight, hypertensive, smoked 20 cigarettes daily, and had a total cholesterol concentration of 8.1 mmol/l; and one had possible familial hypercholesterolaemia and a total cholesterol concentration of 10.7 mmol/l after treatment. MAIN OUTCOME MEASURE: Percentage excess mortality rating.
RESULTS: All companies used explicit criteria to assess the mortality risk associated with hyperlipidaemias, and 47 companies applied the same criteria to men and women. No excess mortality rating was imposed on an applicant with a total cholesterol concentration of 6.4 mmol/l, but a small excess was applied to an applicant with a concentration of 8.1 mmol/l (median excess 50%, range 0-75%). When multiple cardiovascular risk factors were present the same concentration of 8.1 mmol/l resulted in a substantial excess (median 135%, range 50-200%). A smaller but more variable excess was applied to an applicant with possible familial hypercholesterolaemia (median 75%, range 0-200%).
CONCLUSIONS: Despite considerable differences among companies in the excess mortality ratings applied, increases in term life assurance premiums are likely to be restricted to patients with severe hypercholesterolaemia, in particular those with familial hypercholesterolaemia. In the absence of other cardiovascular risk factors milder hypercholesterolaemia is unlikely to result in higher premiums.

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Year:  1991        PMID: 2025730      PMCID: PMC1669222          DOI: 10.1136/bmj.302.6781.891

Source DB:  PubMed          Journal:  BMJ        ISSN: 0959-8138


  8 in total

1.  Screening in practice: Reducing the psychological costs.

Authors:  T M Marteau
Journal:  BMJ       Date:  1990-07-07

2.  Plasma cholesterol concentration and death from coronary heart disease: 10 year results of the Whitehall study.

Authors:  G Rose; M Shipley
Journal:  Br Med J (Clin Res Ed)       Date:  1986-08-02

Review 3.  Psychological costs of screening.

Authors:  T M Marteau
Journal:  BMJ       Date:  1989-08-26

4.  Risks of ischaemic heart-disease in familial hyperlipoproteinaemic states.

Authors:  J Slack
Journal:  Lancet       Date:  1969-12-27       Impact factor: 79.321

5.  Coronary artery disease in 116 kindred with familial type II hyperlipoproteinemia.

Authors:  N J Stone; R I Levy; D S Fredrickson; J Verter
Journal:  Circulation       Date:  1974-03       Impact factor: 29.690

6.  Strategies for reducing coronary heart disease and desirable limits for blood lipid concentrations: guidelines of the British Hyperlipidaemia Association.

Authors:  J Shepherd; D J Betteridge; P Durrington; M Laker; B Lewis; J Mann; J P Miller; J P Reckless; G R Thompson
Journal:  Br Med J (Clin Res Ed)       Date:  1987-11-14

7.  Blood lipid concentrations and other cardiovascular risk factors: distribution, prevalence, and detection in Britain.

Authors:  J I Mann; B Lewis; J Shepherd; A F Winder; S Fenster; L Rose; B Morgan
Journal:  Br Med J (Clin Res Ed)       Date:  1988-06-18

8.  Is relationship between serum cholesterol and risk of premature death from coronary heart disease continuous and graded? Findings in 356,222 primary screenees of the Multiple Risk Factor Intervention Trial (MRFIT).

Authors:  J Stamler; D Wentworth; J D Neaton
Journal:  JAMA       Date:  1986-11-28       Impact factor: 56.272

  8 in total
  5 in total

1.  Effect of statin treatment for familial hypercholesterolaemia on life assurance: results of consecutive surveys in 1990 and 2002.

Authors:  H A W Neil; T Hammond; D Mant; S E Humphries
Journal:  BMJ       Date:  2004-02-28

2.  Improved access to life insurance after genetic diagnosis of familial hypercholesterolaemia: cross-sectional postal questionnaire study.

Authors:  Roeland Huijgen; Sietske J M Homsma; Barbara A Hutten; Iris Kindt; Maud N Vissers; John J P Kastelein; Jan L A van Rijckevorsel
Journal:  Eur J Hum Genet       Date:  2012-02-01       Impact factor: 4.246

Review 3.  A rational approach to treating hypercholesterolaemia in children. Weighing the risks and benefits.

Authors:  S Tonstad
Journal:  Drug Saf       Date:  1997-05       Impact factor: 5.606

4.  Screening for hyperlipidaemia in childhood. Recommendations of the British Hyperlipidaemia Association.

Authors:  R Wray; H Neil; J Rees
Journal:  J R Coll Physicians Lond       Date:  1996 Mar-Apr

Review 5.  Genetic discrimination and life insurance: a systematic review of the evidence.

Authors:  Yann Joly; Ida Ngueng Feze; Jacques Simard
Journal:  BMC Med       Date:  2013-01-31       Impact factor: 8.775

  5 in total

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