Literature DB >> 2025291

A new family of heparin-binding factors: strong conservation of midkine (MK) sequences between the human and the mouse.

J Tsutsui1, K Uehara, K Kadomatsu, S Matsubara, T Muramatsu.   

Abstract

A retinoic acid responsive gene, MK, specifies for a heparin binding factor termed midkine (MK), which is the initial member of a new protein family involved in regulation of growth and differentiation. A cDNA clone of human MK was isolated from a fetal kidney cDNA library. Human MK mRNA was expressed in PA1 teratocarcinoma cells as well as in the kidney. Sequence analysis of the cDNA clone and of a part of the genomic clone yielded the predicted protein sequence of human MK. Human and mouse MK sequences are highly conserved: 87% of amino acids are identical and all amino acid changes are conservative except for an insertion. Comparison of MK and HB-GAM/pleiotrophin (another member of the family) from various species revealed sequences conserved in the family and those specific for each protein.

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Year:  1991        PMID： 2025291     DOI： 10.1016/s0006-291x(05)80255-4

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  24 in total

Review 1.  Structure and function of midkine as the basis of its pharmacological effects.

Authors:  T Muramatsu
Journal:  Br J Pharmacol       Date:  2014-02       Impact factor: 8.739

Review 2.  The midkine family of growth factors: diverse roles in nervous system formation and maintenance.

Authors:  C Winkler; S Yao
Journal:  Br J Pharmacol       Date:  2014-02       Impact factor: 8.739

3.  Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease.

Authors:  Weiwen Wang; Michelle E LeBlanc; Xiuping Chen; Ping Chen; Yanli Ji; Megan Brewer; Hong Tian; Samantha R Spring; Keith A Webster; Wei Li
Journal:  Angiogenesis       Date:  2017-04-26       Impact factor: 9.596

4.  Neointima formation in a restenosis model is suppressed in midkine-deficient mice.

Authors:  M Horiba; K Kadomatsu; E Nakamura; H Muramatsu; S Ikematsu; S Sakuma; K Hayashi; Y Yuzawa; S Matsuo; M Kuzuya; T Kaname; M Hirai; H Saito; T Muramatsu
Journal:  J Clin Invest       Date:  2000-02       Impact factor: 14.808

5.  Muscle reinnervation and IGF-I synthesis are affected by exposure to heparin: an effect partially antagonized by anti-growth hormone-releasing hormone.

Authors:  Laura Madaschi; Anna Maria Di Giulio; Alfredo Gorio
Journal:  Neurochem Res       Date:  2003-01       Impact factor: 3.996

Review 6.  Measuring midkine: the utility of midkine as a biomarker in cancer and other diseases.

Authors:  D R Jones
Journal:  Br J Pharmacol       Date:  2014-06       Impact factor: 8.739

7.  Chromosomal localization of two cell surface-associated molecules of potential importance in development: midkine (Mdk) and basigin (Bsg).

Authors:  D Simon-Chazottes; S Matsubara; T Miyauchi; T Muramatsu; J L Guénet
Journal:  Mamm Genome       Date:  1992       Impact factor: 2.957

Review 8.  Midkine in nephrogenesis, hypertension and kidney diseases.

Authors:  Waichi Sato; Yuka Sato
Journal:  Br J Pharmacol       Date:  2014-02       Impact factor: 8.739

9.  Mapping the midkine family of developmentally regulated signaling molecules.

Authors:  C L Peichel; S W Scherer; L C Tsui; D R Beier; T F Vogt
Journal:  Mamm Genome       Date:  1993-11       Impact factor: 2.957

10.  Targeting of heparanase-modified syndecan-1 by prosecretory mitogen lacritin requires conserved core GAGAL plus heparan and chondroitin sulfate as a novel hybrid binding site that enhances selectivity.

Authors:  Yinghui Zhang; Ningning Wang; Ronald W Raab; Robert L McKown; Jacob A Irwin; Inchan Kwon; Toin H van Kuppevelt; Gordon W Laurie
Journal:  J Biol Chem       Date:  2013-03-15       Impact factor: 5.157
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