Literature DB >> 2025276

ATP-dependent transport for glucuronides in canalicular plasma membrane vesicles.

K Kobayashi1, S Komatsu, T Nishi, H Hara, K Hayashi.   

Abstract

Using rat liver canalicular plasma membrane vesicles, it has been verified that the transport of p-nitrophenyl glucuronide (NPG) across membranes is an ATP-dependent process; the apparent Km for NPG was 20 microM. S-(2,4-dinitrophenyl)-glutathione (DNP-SG) inhibited NPG uptake dose-dependently, and NPG or testosterone glucuronide did ATP-dependent DNP-SG uptake similarly. These results suggest that transport of glucuronide is mediated by an ATP-dependent glutathione S-conjugate carrier.

Entities:  

Mesh：

Substances：

Year:  1991        PMID： 2025276     DOI： 10.1016/s0006-291x(05)80229-3

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  11 in total

1.  Demonstration of a coupled metabolism-efflux process at the choroid plexus as a mechanism of brain protection toward xenobiotics.

Authors:  N Strazielle; J F Ghersi-Egea
Journal:  J Neurosci       Date:  1999-08-01       Impact factor: 6.167

2.  ATP-dependent bile-salt transport in canalicular rat liver plasma-membrane vesicles.

Authors:  B Stieger; B O'Neill; P J Meier
Journal:  Biochem J       Date:  1992-05-15       Impact factor: 3.857

3.  Effects of ursodeoxycholate and its conjugates on biliary glutathione excretion in rats.

Authors:  H Takikawa; N Sano; M Yamanaka
Journal:  Dig Dis Sci       Date:  1996-10       Impact factor: 3.199

4.  Evidence for an UDP-glucuronic acid/phenol glucuronide antiport in rat liver microsomal vesicles.

Authors:  G Bánhegyi; L Braun; P Marcolongo; M Csala; R Fulceri; J Mandl; A Benedetti
Journal:  Biochem J       Date:  1996-04-01       Impact factor: 3.857

5.  Enhanced biliary excretion of lithocholate-3-sulfate by ursodeoxycholate-3,7-disulfate infusion in Eisai hyperbilirubinemic rat (EHBR).

Authors:  H Takikawa; N Sano; T Ogasawara; M Yamanaka
Journal:  Dig Dis Sci       Date:  1998-01       Impact factor: 3.199

6.  MOAT4, a novel multispecific organic-anion transporter for glucuronides and mercapturates in mouse L1210 cells and human erythrocytes.

Authors:  M Saxena; G B Henderson
Journal:  Biochem J       Date:  1996-11-15       Impact factor: 3.857

7.  Mechanisms of biliary excretion of lithocholate-3-sulfate in Eisai hyperbilirubinemic rats (EHBR).

Authors:  H Takikawa; K Nishikawa; N Sano; M Yamanaka; T Horie
Journal:  Dig Dis Sci       Date:  1995-08       Impact factor: 3.199

8.  Adenosine triphosphate-dependent taurocholate transport in human liver plasma membranes.

Authors:  H Wolters; F Kuipers; M J Slooff; R J Vonk
Journal:  J Clin Invest       Date:  1992-12       Impact factor: 14.808

9.  Changes in biliary excretory mechanisms in bile duct-ligated rat.

Authors:  H Takikawa; Y Wako; N Sano; M Yamanaka
Journal:  Dig Dis Sci       Date:  1996-02       Impact factor: 3.199

10.  Organic anions exhibit distinct inhibition patterns on the low-Km and high-Km transport of S-(2,4-dinitrophenyl)glutathione through the human erythrocyte membrane.

Authors:  G Bartosz; H Sies; T P Akerboom
Journal:  Biochem J       Date:  1993-05-15       Impact factor: 3.857
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.