Literature DB >> 2025260

Two cis-acting regulatory sequences in the peroxisome proliferator-responsive enhancer region of rat acyl-CoA oxidase gene.

T Osumi1, J K Wen, T Hashimoto.   

Abstract

To clarify the mechanism of transcriptional induction of the rat liver acyl-CoA oxidase gene by hypolipidemic agents, we searched for cis-acting regulatory sequences in the 5' upstream region of the gene by transfection studies. We found that the sequence between -639 and -472 acts as a peroxisome proliferator-responsive, tissue-specific enhancer. Footprint analysis revealed two protein binding sites in this region. One of these sequences exhibited a positive, whereas the other a negative, regulatory activity in transcription assays.

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Year:  1991        PMID： 2025260     DOI： 10.1016/0006-291x(91)91645-s

Source DB:  PubMed          Journal:  Biochem Biophys Res Commun        ISSN： 0006-291X            Impact factor:   3.575


  30 in total

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3.  Structural and functional characterization of the mouse fatty acid translocase promoter: activation during adipose differentiation.

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4.  Thyromimetic mode of action of peroxisome proliferators: activation of 'malic' enzyme gene transcription.

Authors:  R Hertz; V Nikodem; A Ben-Ishai; I Berman; J Bar-Tana
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5.  Molecular basis of non-responsiveness to peroxisome proliferators: the guinea-pig PPARalpha is functional and mediates peroxisome proliferator-induced hypolipidaemia.

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7.  Aspects of the regulatory mechanisms of PPAR functions: analysis of a bidirectional response element and regulation by sumoylation.

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Review 8.  PPARalpha: energy combustion, hypolipidemia, inflammation and cancer.

Authors:  Sean R Pyper; Navin Viswakarma; Songtao Yu; Janardan K Reddy
Journal:  Nucl Recept Signal       Date:  2010-04-16

9.  Kinase-independent transcriptional co-activation of peroxisome proliferator-activated receptor alpha by AMP-activated protein kinase.

Authors:  Myriam Bronner; Rachel Hertz; Jacob Bar-Tana
Journal:  Biochem J       Date:  2004-12-01       Impact factor: 3.857

10.  Diverse peroxisome proliferator-activated receptors bind to the peroxisome proliferator-responsive elements of the rat hydratase/dehydrogenase and fatty acyl-CoA oxidase genes but differentially induce expression.

Authors:  S L Marcus; K S Miyata; B Zhang; S Subramani; R A Rachubinski; J P Capone
Journal:  Proc Natl Acad Sci U S A       Date:  1993-06-15       Impact factor: 11.205
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