Literature DB >> 2025233

Purification and characterization of truncated ribonuclease inhibitor.

J Hofsteenge1, A Vincentini, S R Stone.   

Abstract

A recombinant pig ribonuclease inhibitor (delta r-RI) lacking 90 or 93 N-terminal amino acid residues was isolated from a preparation of recombinant inhibitor. The kinetic parameters for the inhibition of ribonuclease A by delta r-RI were determined and found to be only slightly altered in comparison with the full-length inhibitor. The deletion did, however, affect the surface properties of RI. The results are discussed in relation to those obtained by Lee & Vallee [(1990) Proc. Natl. Acad. Sci. U.S.A. 87, 1879-1883].

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Year:  1991        PMID： 2025233      PMCID： PMC1150084          DOI： 10.1042/bj2750541

Source DB:  PubMed          Journal:  Biochem J        ISSN： 0264-6021            Impact factor:   3.857


  13 in total

1.  Studies on cellular inhibitors of ribonuclease. II. Some properties of the inhibitor from rat liver.

Authors:  K SHORTMAN
Journal:  Biochim Biophys Acta       Date:  1962-01-22

2.  Kinetics of the inhibition of thrombin by hirudin.

Authors:  S R Stone; J Hofsteenge
Journal:  Biochemistry       Date:  1986-08-12       Impact factor: 3.162

Review 3.  The behavior and significance of slow-binding enzyme inhibitors.

Authors:  J F Morrison; C T Walsh
Journal:  Adv Enzymol Relat Areas Mol Biol       Date:  1988

4.  Modular mutagenesis of human placental ribonuclease inhibitor, a protein with leucine-rich repeats.

Authors:  F S Lee; B L Vallee
Journal:  Proc Natl Acad Sci U S A       Date:  1990-03       Impact factor: 11.205

5.  Kinetic characterization of two active mutants of placental ribonuclease inhibitor that lack internal repeats.

Authors:  F S Lee; B L Vallee
Journal:  Biochemistry       Date:  1990-07-17       Impact factor: 3.162

6.  Transformation of yeast.

Authors:  A Hinnen; J B Hicks; G R Fink
Journal:  Proc Natl Acad Sci U S A       Date:  1978-04       Impact factor: 11.205

7.  Amino acid sequence of the ribonuclease inhibitor from porcine liver reveals the presence of leucine-rich repeats.

Authors:  J Hofsteenge; B Kieffer; R Matthies; B A Hemmings; S R Stone
Journal:  Biochemistry       Date:  1988-11-15       Impact factor: 3.162

8.  Primary structure of human placental ribonuclease inhibitor.

Authors:  F S Lee; E A Fox; H M Zhou; D J Strydom; B L Vallee
Journal:  Biochemistry       Date:  1988-11-15       Impact factor: 3.162

9.  Ribonuclease inhibitor from human placenta. Purification and properties.

Authors:  P Blackburn; G Wilson; S Moore
Journal:  J Biol Chem       Date:  1977-08-25       Impact factor: 5.157

10.  The primary structure of human ribonuclease/angiogenin inhibitor (RAI) discloses a novel highly diversified protein superfamily with a common repetitive module.

Authors:  R Schneider; E Schneider-Scherzer; M Thurnher; B Auer; M Schweiger
Journal:  EMBO J       Date:  1988-12-20       Impact factor: 11.598
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  3 in total

Review 1.  Ribonuclease inhibitor: structure and function.

Authors:  Kimberly A Dickson; Marcia C Haigis; Ronald T Raines
Journal:  Prog Nucleic Acid Res Mol Biol       Date:  2005

2.  Site-specific mutagenesis reveals differences in the structural bases for tight binding of RNase inhibitor to angiogenin and RNase A.

Authors:  C Z Chen; R Shapiro
Journal:  Proc Natl Acad Sci U S A       Date:  1997-03-04       Impact factor: 11.205

3.  Interaction of semisynthetic variants of RNase A with ribonuclease inhibitor.

Authors:  U Neumann; J Hofsteenge
Journal:  Protein Sci       Date:  1994-02       Impact factor: 6.725
  3 in total

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